The utility of previously generated microarray data is severely limited owing to small study size, leading to under-powered analysis, and failure of replication. Multiplicity of platforms and various sources of systematic noise limit the ability to compile existing data from similar studies. We present a model for transformation of data across different generations of Affymetrix arrays, develop...

The ACLAME database (http://aclame.ulb.ac.be) is a collection and classification of prokaryotic mobile genetic elements (MGEs) from various sources, comprising all known phage genomes, plasmids and transposons. In addition to providing information on the full genomes and genetic entities, it aims to build a comprehensive classification of the functional modules of MGEs at the protein, gene and ...

Physalis alkekengi L. has been used as anti-infective plant in Iranian traditional medicine. To investigate antifungal activity of the plant extract, wild plant was collected and identified and the aerial parts were air dried and powdered subsequently macerated in solvent. Extracts were concentrated by rotary evaporator at 60 C under reduced pressure. Aqueous, ethanol and methanol extracts were...

Varicella-zoster virus (VZV) open reading frame 63 (ORF63) protein is expressed during latency in human sensory ganglia. Deletion of ORF63 impairs virus replication in cell culture and establishment of latency in cotton rats. We found that cells infected with a VZV ORF63 deletion mutant yielded low titers of cell-free virus and produced very few enveloped virions detectable by electron microsco...