The c-Myc oncogenic transcription factor (Myc) is pathologically activated in many human malignancies. Myc is known to directly upregulate a pro-tumorigenic group of microRNAs (miRNAs) known as the miR-17–92 cluster. Through the analysis of human and mouse models of B cell lymphoma, we show here that Myc regulates a much broader set of miRNAs than previously anticipated. Unexpectedly, the predo...

Professor Eitan Tadmor turned 50 earlier this year. He is one of the most active and influential mathematicians in the area of numerical analysis, general theory of applied PDEs, and scientific computing. He has influenced the field of applied mathematics in many ways: through his deep and broad mathematical research, his strong efforts in advising, training, and mentoring young scientists, and...

Architectural design – the art and science of designing space, building and the built environment – is a creative and complex task. It involves considerations of form (shapes, structure and configurations) and function (purposes and utilities). Whether form precedes function or vice versa (Janson, 1982; Anderson, 1987), the training and education of architects posits that successful design shou...

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue,we havegenerated composite tamoxifen-inducible intestine-specific genetic mouse...

The development of the diagnostic and classification criteria for headache disorders from the International Headache Society has benefited not only practicing headache specialists but also epidemiologists. We now have a wealth of data from international epidemiological studies on the prevalence and cost of migraine and other headache disorders. The data reveal the significant impact these disor...

Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been elucidated. Lis1 deficiency is associated with deregulation of the Rho-family GTPas...

Synopsis Cave-adapted animals are characterized by extreme reduction or complete absence of eyes, reflecting their lack of exposure to daylight. Given the overall constancy of abiotic variables in the cave environment, one would also expect the relaxation and eventual loss of circadian rhythms, and with it, the regressive evolution of the underlying genetic biological clock. Remarkably, however...

Prediction of drug–drug interactions due to cytochrome P450 isoform 3A4 (CYP3A4) overexpression is important because this CYP isoform is involved in the metabolism of about 30% of clinically used drugs from almost all therapeutic categories. Therefore, it is mandatory to attempt to predict the potential of a new compound to induce CYP3A4. Among several in vitro–in vivo extrapolation methods rec...