نتایج جستجو برای: 5 fluorouracil 5 fu
تعداد نتایج: 1223700 فیلتر نتایج به سال:
A new family of antitumor prodrugs (1-3) of 5-fluorouracil (5-FU) possessing photolabile 2-nitrobenzyl chromophores have been designed and synthesized to investigate the efficiency and mechanism of photoactivated 5-FU release upon UV-irradiation at lambda(ex)= 365 nm. The photoactivated prodrug 3 derived from conjugation of 2 with a tumor-homing cyclic peptide Cys-Asn-Gly-Arg-Cys (CNGRC) was so...
Objectives. Chemotherapy is considered to be essential in the treatment of patients with colorectal cancer (CRC), but drug resistance reduces its efficacy. Many advanced CRC eventually show 5-fluorouracil (5-FU) therapy. Synergistic and potentiating effects combination therapy, using herbal chemical drugs, can improve patients’ response. Zerumbone (ZER), which derived from ginger, has been stud...
We studied the stability of 5-fluorouracil (5-FU) in plasma and whole blood kept at room temperature and on ice for 1 to 24 h. At room temperature, there was a steady loss of 94% of the parent drug over 24 h in whole blood and 52% in plasma. In the presence of an excess of uracil, 5-FU was stable for 24 h, suggesting that the loss of 5-FU is the result of enzymatic degradation. 5-FU is more sta...
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A 37-year-old female with gastric cancer underwent a curative operation, followed by adjuvant chemotherapy consisting of 5-FU and epirubicin. After the first cycle of chemotherapy...
We present a case of a Caucasian cancer patient undergoing 5-fluorouracil (5-FU)-containing chemotherapy in our department. The 49-year-old female patient suffered from adverse effects representing WHO grade 3 toxicity. Genotyping revealed that she carried the exon 14-skipping mutation which is known to result in dehydropyrimidine dehydrogenase (DPD) deficiency. DPD is the enzyme that converts ...
It has been shown previously ( 15) that photoperiodic induction in Xanthium is inhibited by application of the pyrimidine, 5-fluorouracil (5-FU). More recently (1) it has been demonstrated that the process which is inhibited by 5-FU and which is related to the process of flowering, is the synthesis of ribonucleic acid (RNA) in the Xanthium bud during the first part of the inductive dark period....
Fluoropyrimidines are the chemotherapy backbone in the treatment of adenocarcinoma of the colon. Adjuvant 5-fluorouracil (5-FU)/leucovorin (LV) has been shown to significantly increase recurrence-free survival compared to surgery alone for patients with stage III colon cancer. Furthermore, the addition of oxaliplatin to 5-FU/LV (FOLFOX) in the adjuvant setting has been shown to provide an impro...
Hepatocellular carcinoma (HCC) is one of the few cancers in which a continuous increase in incidence has been observed over several years. Drug resistance is a major problem in the treatment of HCC. In the present study, we used salinomycin (Sal) and 5-fluorouracil (5-FU) combination therapy on HCC cell lines Huh7, LM3 and SMMC-7721 and nude mice subcutaneously tumor model to study whether Sal ...
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