نتایج جستجو برای: 5α dihydrotestosterone

تعداد نتایج: 3573  

Journal: :Molecules 2012
Jing Xu Daqing Jin Ping Guo Chunfeng Xie Lingzhi Fang Yuanqiang Guo

Three new myrsinol diterpenes were isolated from the roots of Euphorbia prolifera. Their structures were elucidated as 2α-O-isobutyryl-3β,5α,7β,10,15β-penta-O-acetyl-14α-O-benzoyl-10,18-dihydromyrsinol (1), 2α-O-isobutyryl-3β-O-propion-yl-5α,7β,10,15β-tetra-O-acetyl-10,18-dihydromyrsinol (2), and 2α,14α-di-O-benzoyl-3β,5α,7β,10,15β-penta-O-acetyl-10,18-dihydromyrsinol (3) on the basis of spectr...

Journal: :Molecules 2013
Wei-Hsuan Yen Wu-Fu Chen Ching-Hsiao Cheng Chang-Feng Dai Mei-Chin Lu Jui-Hsin Su Yin-Di Su Yu-Hsin Chen Yu-Chia Chang Yung-Husan Chen Jyh-Horng Sheu Chan-Hsing Lin Zhi-Hong Wen Ping-Jyun Sung

A new sterol, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methyl-cholest-6,9(11)-dien-3β-ol (1), and two known sterols, (22R,23R,24R)-5α,8α-epidioxy-22,23-methylene-24-methylcholest-6-en-3β-ol (2) and 24-methylenecholestane-1α,3β,5α, 6β,11α-pentol (3), were isolated from the soft coral Sinularia gaweli. The structure of sterol 1 was established by spectroscopic methods and by comparison of ...

Journal: :Phytochemistry 2012
Hui-Chi Huang Chih-Chuang Liaw Hsin-Ling Yang You-Cheng Hseu Hsiou-Ting Kuo Yao-Ching Tsai Shih-Chang Chien Sakae Amagaya Yu-Chang Chen Yueh-Hsiung Kuo

Four lanostane triterpenes, 3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, two sterols, (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione and a steroid named as camphosterol A were isolated from a mixture of fruiting bodies and...

Journal: :Steroids 2013
Jiesi Chen Tiandong Leng Wenli Chen Min Yan Wei Yin Yijun Huang Suizhen Lin Dayue Duan Jun Lin Gongxiong Wu Jingxia Zhang Guangmei Yan

Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods of ischemia following reperfusion in ischemic stroke, not only loss of energy supply, but a few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized a steroid compound 5α-androst-3β,5,6β-triol by 3 steps starting ...

2016
Antoniette M. Maldonado-Devincci Alexander Kampov-Polevoi Raechel E. McKinley Danielle H. Morrow Todd K. O’Buckley A. Leslie Morrow

The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) is decreased in various brain regions of C57BL/6J mice following exposure to an acute stressor or chronic intermittent ethanol (CIE) exposure and withdrawal. It is well established that there are complex interactions between stress and ethanol drinking, with mixed literature regarding the effects of...

Journal: :Journal of lipid research 2011
Xuntian Jiang Rohini Sidhu Forbes D Porter Nicole M Yanjanin Anneliese O Speak Danielle Taylor te Vruchte Frances M Platt Hideji Fujiwara David E Scherrer Jessie Zhang Dennis J Dietzen Jean E Schaffer Daniel S Ory

Niemann-Pick type C1 (NPC1) disease is a rare, progressively fatal neurodegenerative disease for which there are no FDA-approved therapies. A major barrier to developing new therapies for this disorder has been the lack of a sensitive and noninvasive diagnostic test. Recently, we demonstrated that two cholesterol oxidation products, specifically cholestane-3β,5α,6β-triol (3β,5α,6β-triol) and 7-...

2012
Zachary J. Hall Scott A. MacDougall-Shackleton

The song-control system is a network of discrete nuclei in the songbird brain that controls the production and learning of birdsong and exhibits some of the best-studied neuroplasticity found in the adult brain. Photoperiodic growth of the song-control system during the breeding season is driven, at least in part, by the gonadal steroid testosterone. When acting on neural tissue, however, testo...

2016
Satwant Kaur Alice Baynes Anne E Lockyer Edwin J Routledge Catherine S Jones Leslie R Noble Susan Jobling

Gastropod mollusks have been proposed as alternative models for male reproductive toxicity testing, due to similarities in their reproductive anatomy compared to mammals, together with evidence that endocrine disrupting chemicals can cause effects in some mollusks analogous to those seen in mammals. To test this hypothesis, we used the freshwater pulmonate snail, Biomphalaria glabrata, for whic...

Journal: :Journal of molecular endocrinology 2012
Andrew P Trotta Eleanor F Need Lisa M Butler Luke A Selth Melissa A O'Loughlin Gerhard A Coetzee Wayne D Tilley Grant Buchanan

Ligand-dependent activity of steroid receptors is affected by tetratricopeptide repeat (TPR)-containing co-chaperones, such as small glutamine-rich tetratricopeptide repeat-containing alpha (SGTA). However, the precise mechanisms by which the predominantly cytoplasmic TPR proteins affect downstream transcriptional outcomes of steroid signaling remain unclear. In this study, we assessed how SGTA...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید