Abstract We present the first JWST spectral energy distribution of a Y dwarf. This Y0 dwarf WISE J035934.06−540154.6 consists low-resolution ( λ /Δ ∼100) spectroscopy from 1–12 μ m and three photometric points at 15, 18, 21 m. The spectrum exhibits numerous fundamental, overtone, combination rotational–vibrational bands H 2 O, CH 4 , CO, CO NH 3 including previously unidentified ν band Using Ra...

BACKGROUND Apolipoprotein B mRNA-editing catalytic polypeptide like-3G (APOBEC3G) is an antiviral enzyme that reduces viral fitness by introducing uracil to thymidine hypermutations in viral genomes. Thus, polymorphisms in the APOBEC3G gene have been implicated in differential outcomes of HIV infection and disease progression. However, there is insufficient evidence on the role of APOBEC3G gene...

OBJECTIVE Studies showing the effectiveness of therapeutic hypothermia (32-34°C) in postcardiac arrest patients have been criticized because of patients with elevated body temperature (>37.5°C) in the noncooled control group. Thus, the effects of spontaneous normothermia (<37.5°C) compared with mild therapeutic hypothermia were studied. DESIGN Retrospective chart review from 1991 to 2010. P...

WRN protein, defective in Werner syndrome (WS), a human segmental progeria, is a target of serine/threonine kinases involved in sensing DNA damage. DNA-PK phosphorylates WRN in response to DNA double strand breaks (DSBs). However, the main phosphorylation sites and functional importance of the phosphorylation of WRN has remained unclear. Here, we identify Ser-440 and -467 in WRN as major phosph...

INTRODUCTION................................................................................... 450 I. COPYRIGHTS AND LICENSING................................................ 452 A. The Basics........................................................................... 452 B. Computer Software ............................................................ 454 1. The Special Problem of Derivative W...

From the Laboratory for Behavioral Genetics 1 , RIKEN BSI, Wako, Saitama 351-0198, Japan; the Department of Molecular Pharmacology 2 , Medical Research Institute, and Center of Excellence Program for Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical & Dental University, Chiyoda, Tokyo 101-0062, Japan; the Department of Molecular Immunology 3 , Graduate School of Agricult...

Historical Background 461 Types of Insulin 461 Rapid-Acting Insulins 461 Intermediate-Acting Insulins 462 Long-Acting Insulins 462 Insulin Purity, Species, and Concentration 463 Beef and Pork Insulins 463 Human Insulin 463 Insulin Concentrations 464 Initiation of Insulin Therapy 464 Coals of Therapy 465 Treatment Strategies 466 Single-Dose Regimens 466 Twice-Daily Regimens 467 Multiple Daily In...

We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Reporter constructs of hPAP promoter covering the region -734/+467 were functional in both prostatic (LNCaP and PC-3) and nonprostatic (CV-1) cell lines in transient transfections. hPA...

BACKGROUND Compelling epidemiological evidence indicates that alterations of telomere length are associated with risks of many malignancies in a tumor-specific manner, such as lung cancer, breast cancer, and non-Hodgkin's lymphoma. However, the association between leukocyte telomere length and glioma risk has not been investigated. METHODS Relative telomere length (RTL) of peripheral blood le...