Masashi Kusukawa and Hajime Iwamura Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Z. Naturforsch. 50c, 373-379 (1995); received January 2/February 17, 1995 N-Phenylcarbamates, Flower Induction. Asparagus officinalis, Cytochrome P-450. N-(3,4-Methylenedioxyphenyl)carbamates and related compounds were prepared to de­ velop flower-inducing compoun...

We have investigated the response of rat liver nuclear, nu clear envelope, and microsomal cytochrome P-450 (or P-448) to various treatments. Responses of these subcellular fractions to 3-methylcholanthrene pretreatment were generally similar. In endoplasmic reticulum preparations, we observed an in crease in cytochrome P-450 content following phénobarbital pretreatment, which was reduced by su...

Aflatoxin Bi, the most potent hepatic chemical carcinogen known, is activated to the putative product aflatoxin B,-2,3epoxide via a cytochrome P-450-dependent reaction. Mt. Shasta rainbow trout is the most sensitive species known to the hepatocarcinogenic effects of aflatoxin B,. We have previously iso lated and purified a minor form of cytochrome P-450 from this strain of rainbow trout, with a...

We determined the coding nucleotide sequence of the mRNA for a 3-methylcholanthrene-inducible cytochrome P-450, P-450d, of rat liver by sequence analysis of cloned cDNAs. The predicted amino acid sequence of the cytochrome is composed of 513 amino acids, and its NH2-terminal sequence of 30 amino acids completely coincides with that reported from analysis of the purified cytochrome P-450d. The a...

The interaction of cytochromes P-450 of the liver and olfactory epithelium of male hamsters with cumene hydroperoxide (CHP) has been characterized with regard to the ability of CHP to (1) support 7-ethoxycoumarin-O-de-ethylase (ECOD) activity, (2) support the oxidation of NNN'N'-tetramethyl-p-phenylenediamme (peroxidase activity) and (3) cause inactivation of cytochrome P-450. In the liver, CHP...