RESULTS. TNFinduced a timeand concentration-dependent decrease in GJIC activity in human corneal fibroblasts. Immunofluorescence analysis revealed that TNFreduced the level of specific staining for Cx43 at sites of contact between adjacent cells. Immunoblot analysis detected four specific Cx43 bands, one corresponding to the nonphosphorylated form of the protein and three corresponding to phosp...

At the request of a special class teacher in a Philadelphia school, who is also a student in psychology at the University, an examination was made of eighteen orthogenic backward cases, comprising her special class, and forty-three suspects from grades one to six inclusive. These suspects were chosen by their grade teacher, either because of failure to be promoted, or on account of other stigma...

Previous studies show that chemical regulation of connexin43 (Cx43) gap junction channels depends on the integrity of the carboxyl terminal (CT) domain. Experiments using Xenopus oocytes show that truncation of the CT domain alters the time course for current inactivation; however, correlation with the behavior of single Cx43 channels has been lacking. Furthermore, whereas chemical gating is as...

OBJECTIVE To evaluate the injury risk associated with indoor rock climbing competition. METHODS All injuries reported to medical personnel at the 2005 World Championships in Rock Climbing were recorded and analyzed. RESULTS Four hundred forty-three climbers (273 men, 170 women) from 55 countries participated in 3 separate disciplines totaling 520 climbing days. Only 4 of 18 acute medical pr...

Commercially available electronic prescribing systems may differ in their effects on patients' health outcomes and on patients' ability to manage costs. An expert panel convened to recommend specific features that would enable electronic prescribing systems to advance these goals. The panel authored sixty recommendations and rated each using a modified Delphi process. Ratings identified fifty-t...