Newcastle disease virus (NDV) exhibits oncolysis in its natural form. This oncolytic (OV) has the potential to specifically infect, propagate, and lyse cancer cells while sparing normal cells. study was aimed screen for NDV strain isolated from poultry. A total of ten velogenic strains were propagated 10 day old embryonated SPF chicken eggs allantoic fluid these infected collected further study...

A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against t...

in order to identify and selection salt tolerant hybrids based on tolerance indices, 17 sugar beet three-way cross hybrids produced by crosses between 17 salinity improved s1 pollinators and a cytoplasmic male sterile (cms) single cross as female, along with three control genotypes were grown in 2007 in rudasht station (isfahan) under saline (12 ds/m and 8 ds/m for water and soil) and non-salin...

Abstract Background Breast cancer is the most frequently diagnosed malignancy among women. However, role of microRNA (miRNA) expression in breast progression not fully understood. In this study we examined predictive interactions between differentially expressed miRNAs and mRNAs cell lines representative common molecular subtypes. Integrative bioinformatics analysis identified miR-193 miR-210 a...

Detection of cytokeratin-19 (CK19) expression as an epithelial-specific marker in circulating tumor cells (CTCs) of breast cancer patients can be important for diagnostic purposes. Comparison of CK19 expression in breast cancer cell lines can indicate that expression of this marker is different in various breast cancer cell lines based on their category. Thirty-five breast cancer patients were ...

objective(s): nowadays, cancer is an important public health problem in all countries. limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   materials and methods: a new series...

Lauryl gallate is an antioxidant food additive showing low toxicity to normal cells. Here, its antiproliferative effect has been studied on three human breast cancer cell lines: estrogen-dependent, wild-type p53, MCF7; estrogen-independent, non-functional p53, MDA-MB-231 and MCF7 ADR, which overexpresses P-glycoprotein (P-gp) and displays a multidrug-resistant phenotype. Lauryl gallate inhibite...

Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts. Here, we find that Girdin is expressed in a variety of cancer cell lines, including the breast cancer cell line MDA-MB-231, and is phosphorylated by the stimulation of insulin-like growth factor (IGF-I). In vitro migration ...

Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first tim...