BACKGROUND/AIMS Angiotensin II (AngII) type 1 receptor (AT1R) could be activated by mechanical stress without the involvement of AngII during the development of cardiac hypertrophy. We aimed to identify sensing sites of AT1R for activation by mechanical stretch. METHODS We constructed several site-directed mutations of AT1R (AT1R(K199Q), AT1R(L212F), AT1R(Q257A) and AT1R(C289A)), transfected ...

Mechanical load as stimulus for apoptosis and necrosis could be responsible for the loss of cardiomyocytes. Ventricular myocytes from young (3 mo) and old (14-24 mo) rats underwent cyclical mechanical stretch (CMS; 5% elongation, 1 Hz) for 24 h. Spontaneous apoptosis was in myocytes from young rats 0.33 +/- 0.12% and from old rats 1.05 +/- 0.35% [Tdt-mediated dUTP nick-end labeling (TUNEL) assa...

BACKGROUND Human genetically inherited cardiac diseases have been studied mainly in heterologous systems or animal models, independent of patients' genetic backgrounds. Because sources of human cardiomyocytes (CMs) are extremely limited, the use of urine samples to generate induced pluripotent stem cell-derived CMs would be a noninvasive method to identify cardiac dysfunctions that lead to path...

The purpose of the study was to compare electrical stimulation (ES) and cervical magnetic stimulation (CMS) of the phrenic nerves for the measurement of the diaphragm compound muscle action potential (CMAP) and phrenic nerve conduction time. A specially designed esophageal catheter with three pairs of electrodes was used, with control of electrode positioning in 10 normal subjects. Pair A and p...

AIM Complex motor stereotypies (CMS) are patterned, repetitive, rhythmic, and involuntary movements that persist over time. They are divided into two subgroups dependent on the presence of other developmental problems: 'primary' (development is otherwise typical) or 'secondary' (associated with autism, intellectual disability, or sensory deficits). There are no currently published studies that ...

INTRODUCTION In this study we investigated muscle magnetic resonance imaging in congenital myasthenic syndromes (CMS). METHODS Twenty-six patients with 9 CMS subtypes and 10 controls were imaged. T1-weighted (T1w) and short-tau inversion recovery (STIR) 3-Tesla MRI images obtained at thigh and calf levels were scored for severity. RESULTS Overall mean the T1w score was increased in GFPT1 an...

In this article the authors offer a faculty perspective on desirable features of a Course Management System (CMS). This article is the result of our Web teaching experiences over a period of eight years using three different CMS platforms. The authors anticipate that this article could help guide software developers in developing appropriate CMS tools and would help institutions to gain greater...

Web applications are evolving towards strong content-centered Web applications. The development processes and implementation of these applications are unlike the development and implementation of traditional information systems. In this paper we propose WebEngineering Method; a method for developing content management system (CMS) based Web applications. Critical to a successful development of ...

The management of compliance with rules, policies, guidelines, practices, and standards is largely done through a manual and labour-intensive process. This process can be facilitated through the use of a computer-based Compliance Management System (CMS). A CMS identifies compliance tasks, tracks the performance of these tasks with respect to a set of requirements and documents their compliance ...

  This paper deals with the cellular manufacturing system (CMS) that is based on group technology concepts. CMS is defined as identifying the similar parts that are processed on the same machines and then grouping them as a cell. The most proposed models for solving CMS are focused on cell formation problem while machine layout is considered in few papers. This paper addresses a mathematical mo...