BACKGROUND AND PURPOSE We wished to test the validity of a stroke probability point system from the Framingham Study for a sample of the population of Copenhagen, Denmark. In the Framingham cohort, the regression model of Cox established the effect on stroke of the following factors: age, systolic blood pressure, the use of antihypertensive therapy, diabetes mellitus, cigarette smoking, prior c...

Approximately 15 years ago it was discovered that the bone marrow and blood harbor stem cells with angiogenic potential.1 Because some of these stem cells express endothelial markers, it is believed that they are endothelial progenitor cells (EPCs) that will contribute to the maintenance of the circulatory system and develop into adult endothelial cells. Many studies followed to unravel the phy...

Prorenin, the precursor of renin, exists in circulating blood at concentrations that are 5 to 10 higher than those of renin. For many years, prorenin was considered to be an inactive form of renin with no physiological role. Then, in the mid-80s of the last century, Luetscher et al reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects.1 Subsequent s...

Plague in humans is caused by the gram-negative bacterium Yersinia pestis (6). The disease is 50 to 100% fatal if untreated and potentially could be caused on an epidemic scale by a malicious act. Accordingly, there is a need to understand the pathogenesis of Y. pestis and to enhance resistance to plague in people. A major virulence property of the plague-causing bacteria is the production of a...

Recently, we developed a technique that allows the in uiuo visualization in man of somatostatin receptor-positive neuroendocrine tumors after iv injection of [iZ31-Tyr3]octreotide or [“‘In-DTPA-nPhe’loctreotide. Radiotherapy of such tumors using somatostatin analogs coupled to OLor P-emitting radionuclides has been proposed as an application for radiolabeled somatostatin analogs. To develop thi...

This study is to understanding the transcription profile of human Glucocorticoid Receptor GR, gene of a neuroendocrine, stress response and obesity related receptor. For GR, relative luciferase activity RLA and the distribution of phosphorylation [P], glycosylation sites [G] on transcription factor for promoter model were plotted on the same chart. Within the 3.2 kb upstream of the methionine A...

Objectives. Febrile seizures recur frequently. Factors increasing the risk of febrile seizure recurrence include young age at onset, family history of febrile seizures, previous recurrent febrile seizures, time lapse since previous seizure <6 months, relative low temperature at the initial seizure, multiple type initial seizure, and frequent febrile illnesses. Prevention of seizure recurrences ...

Approximately 15 years ago it was discovered that the bone marrow and blood harbor stem cells with angiogenic potential.1 Because some of these stem cells express endothelial markers, it is believed that they are endothelial progenitor cells (EPCs) that will contribute to the maintenance of the circulatory system and develop into adult endothelial cells. Many studies followed to unravel the phy...

Excessive deposition of fibronectin in the glomerular mesangium in diabetic nephropathy (DN) is partly due to the induction of transforming growth factor(TGF) by high glucose. TGFinduces its downstream mediator connective tissue growth factor (CTGF), which stimulates fibronectin matrix synthesis, a process that requires the presence of 5 1 integrin. Although TGFhas been shown to upregulate 5 1 ...

Purpose: To control for confounding bias from non-random treatment assignment in observational data, both traditional multivariable models and more recently propensity score approaches have been applied. Our aim was to compare a propensity score-stratified model with a traditional multivariable-adjusted model, specifically in estimating survival of hemodialysis (HD) versus peritoneal dialysis (...