New edaravone derivatives containing a benzylpiperazine moiety are designed and synthesized. The structures characterized by 1 H NMR, 13 C high-resolution mass spectrometry. potential neuroprotective activities of the target compounds evaluated in differentiated rat pheochromocytoma cells (PC12 cells) mice subjected to acute cerebral ischemia. Most showed both vivo vitro, especially 1-(4-(4-flu...

The synthesis of a new 4-[2-(1-methyl-1H-imidazol-2-ylsulfanyl)-acetylamino]-benzenesulfonic acid from available reagents using an efficient strategy was reported, and its antimicrobial ability against bacterial strains investigated. This compound characterised single crystal technique, which showed that the crystallised with monoclinic system in P21/c space group. Its unit-cell parameters were...

In the title compound {systematic name: 4-chloro-N-[1-(1H-imidazol-1-yl)-2-propoxyethyl-idene]-2-(trifluoro-meth-yl)aniline}, C(15)H(15)ClF(3)N(3)O, the dihedral angle between the aniline and imidazole ring planes is 81.80 (4)°. In the crystal structure, weak inter-molecular C-H⋯X (X = N, O or F) hydrogen bonds and C-H⋯π inter-actions help to consolidate the packing.

A series of six 4-arylidene-2-phenyl-1-(4-(3-phenylacryloyl)phenyl)-1H-imidazol-5(4H)ones (8a-f) have been synthesized by condensation of 1-(4-acetylphenyl)-4-arylidene-2phenyl-1H-imidazol-5(4H)-ones (7a-e) with different aryl aldehydes (4a, 4c, 4f). The structures of the newly synthesized compounds were characterized by FT-IR, H NMR, C NMR and Mass spectral studies. All the final compounds syn...