Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious immune-related toxicity. Recently, a mutant of IL2 (IL2v) with abolished CD25 binding, increased plasma half-life and less toxicity was engineered. Unlike wild-type IL2 (wt-IL2), mutant IL2v does not bind to the α-subunit (CD25) of the hig...

This paper describes a low-voltage, low-jitter clock synthesizer and a temperaturecompensated tunable oscillator. Both of these circuits employ a self-correcting Delay-Locked Loop (DLL) which solves the problem of false locking associated with conventional DLLs. This DLL does not require the delay control voltage to be set on power-up, it can recover from missing reference clock pulses and beca...

We have previously found that monkey Vgamma2Vdelta2(+) T cells mount adaptive immune responses in response to Mycobacterium bovis bacillus Calmette-Guérin infections. We have now analyzed rhesus monkey gammadelta T cell responses to nonpeptide Ags and superantigens. Like human Vgamma2Vdelta2(+) T cells, rhesus monkey gammadelta T cells are stimulated when exposed to prenyl pyrophosphate, bispho...

The title structure, (C(11)H(20)BrN(2))[Ag(CN)(2))], is built up from an approximately C(2v)-symmetric imidazolium cation and a nearly linear dicyanidoargentate anion [N-Ag-N = 176.6 (9)° and Ag-C-N = 178.8 (9) and 177.2 (11)°]. These two constituents are linked by a remarkably short inter-action between the Br atom of the imidazolium cation [C-Br = 1.85 (3) Å] and one N atom of the cyanidoarge...

We consider the following phenomenon: with just one multiplication we can compute (3u+2v)(3x+2y) ≡ 3ux+4vy (mod 6), while computing the same polynomial modulo 5 needs 2 multiplications. We generalize this observation and we define some vectors, called sixtors, with remarkable zero-divisor properties. Using sixtors, we also generalize our earlier result (Computing Elementary Symmetric Polynomial...

This paper is concerned with the relationships between L differentiability and Sobolev functions. It is shown that if / is a Sobolev function with weak derivatives up to order k in L , and 0 s / s k, then / has an L derivative of order / everywhere except for a set which is small in the sense of an appropriate capacity. It is also shown that if a function has an 2V derivative P everywhere excep...