background: canine parvovirus (cpv) infection is one ofthe most common causes of infectious gastroenteritis in dogs andis a highly contagious, often fatal disease. the original virus(cpv type 2) has had some mutations since its emergence andnew variants (cpv-2a, 2b and 2c) have been reported from manycountries all around the world. early diagnosis and treatment canprofoundly affect the disease ...

BackgroundCurrent staging systems for cutaneous squamous cell carcinoma (cSCC) have limited positive predictive value identifying patients who will experience metastasis.ObjectiveTo develop and validate a gene expression profile (GEP) test predicting risk metastasis in localized, high-risk cSCC with the goal of improving risk-directed patient management.MethodsArchival formalin-fixed paraffin-e...

We have recently identified a promoter proximal retinoic acid (RA)-responsive site in the 5' region of the HOXB1 gene. In this report, we have identified the second RA-responsive site in the 3' region of the HOXB1 gene. This site also consists of a DR-2-type target of RA receptor.retinoid X receptor complex (DR-2B) and the binding site for a distinct RA-dependent coactivator termed retinoid-act...

cAMP stimulates the transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK) in rat liver. We have investigated the nucleotide sequences required for regulation of PEPCK gene expression by cAMP. A chimeric gene was constructed in which a 620-base pair fragment of the 5'-end of the PEPCK gene (including 547 base pairs of 5'-flanking sequen...

background egypt has one of the highest (16-8%) prevalence rates of hcv infection in the world. approximately 90% of egyptian hcv isolates belong to a single subtype (4a), which responds less successfully to interferon therapy than other subtypes. studies comparing the efficacy and safety of pegifn alfa-2a and pegifn alfa-2b in treatment-naive hcv-infected patients have shown conflicting result...

background: dysregulation of wnt signaling has been reported in many malignancies. objective: this study was conducted to investigate the expression pattern of 14 members of the wnt gene family in different immunophenotypic subtypes of all. methods: semi-quantitative rt-pcr was performed on samples from 71 all patients and 36 age-matched healthy individuals. the all patients were categorized in...

ATP-binding cassette subfamily C (ABCC) genes code for phase III metabolism proteins that translocate xenobiotic (e.g., particulate matter 2.5 (PM2.5)) and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC transporters. This study assesses ABCC1-4 gene expression changes and proinflammatory cytokine (IL-6, IL-8) release in human bronchial epithelial c...

Hexavalent chromium [Cr(VI)] is an important human carcinogen associated with pulmonary diseases and lung cancer. Inhibition of Cr(VI)-induced carcinogenesis by a dietary antioxidant is a novel approach. Quercetin is one of the most abundant dietary flavonoids widely present in many fruits and vegetables, possesses potent antioxidant and anticancer properties. MicroRNA-21 (miR-21) is a key onco...

Root-lesion nematodes (RLNs) Pratylenchus thornei and P. neglectus are globally important pathogens of cereal pulse crops. These RLNs can occur together in farming systems must be managed concurrently to minimize substantial yield losses intolerant crop cultivars. Australian wheat cultivars with resistance neglectus, have either the Rlnn1 gene, which provides a high level but is linked yellow f...

The complement system is an innate immune pathway that in vertebrates, is responsible for initial recognition and ultimately phagocytosis and destruction of microbes. Several complement molecules including C3, Factor B, and mannose binding lectin associated serine proteases (MASP) have been characterized in invertebrates and while most studies have focused on their conserved role in defense aga...