نتایج جستجو برای: 293 t با بیان بالای tim3

تعداد نتایج: 1356535  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Edmund K Moon Liang-Chuan Wang Douglas V Dolfi Caleph B Wilson Raghuveer Ranganathan Jing Sun Veena Kapoor John Scholler Ellen Puré Michael C Milone Carl H June James L Riley E John Wherry Steven M Albelda

PURPOSE Immunotherapy using vaccines or adoptively transferred tumor-infiltrating lymphocytes (TIL) is limited by T-cell functional inactivation within the solid tumor microenvironment. The purpose of this study was to determine whether a similar tumor-induced inhibition occurred with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR) targeting tumor-associated a...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Edmund K Moon Raghuveer Ranganathan Evgeniy Eruslanov Soyeon Kim Kheng Newick Shaun O'Brien Albert Lo Xiaojun Liu Yangbing Zhao Steven M Albelda

PURPOSE Tumor-infiltrating lymphocytes (TILs) become hypofunctional, although the mechanisms are not clear. Our goal was to generate a model of human tumor-induced TIL hypofunction to study mechanisms and to test anti-human therapeutics. EXPERIMENTAL DESIGN We transduced human T cells with a published, optimized T-cell receptor (TCR) that is directed to a peptide within the cancer testis anti...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Arnaud Delpoux Chen-Yen Lai Stephen M Hedrick Andrew L Doedens

The factors and steps controlling postinfection CD8+ T cell terminal effector versus memory differentiation are incompletely understood. Whereas we found that naive TCF7 (alias "Tcf-1") expression is FOXO1 independent, early postinfection we report bimodal, FOXO1-dependent expression of the memory-essential transcription factor TCF7 in pathogen-specific CD8+ T cells. We determined the early pos...

ژورنال: پژوهش در پزشکی 2006
نژاد مقدم, محمدرضا, چمن‌خواه, محمود, باباشمسی, محمد, مدرسی, سیدمحمدحسین,

Abstract: Background: Streptokinase has been widely prescribed as a fibrinolytic agent for myocardial infarction. Simple structural characteristics of this protein have provided techniques for production of different recombinant types of this protein. The present study was designed to prepare equisimilisH46A subtype of streptokinase in our country. Materials and methods: Having extracted the...

ژورنال: :فصلنامه علمی ـ پژوهشی زیست فناوری گیاهان زراعی 2013
ناهید احمدی حسن رهنما

بیان موقت ژن­های بیگانه در بافت­های گیاهی برای آنالیز عملکرد ژن در زمان کوتاه روش کارآمدی می­باشد. این روش سریع، انعطاف پذیر، ساده و در بافت­های تمایز یافته قابل اجرا است. پیشبر 2a11 از پیشبرهای ویژه بافت میوه گیاه گوجه­فرنگی است که باعث بیان بالای ژن 2a11 در میوه می­شود. هدف از این تحقیق همسانه­سازی پیشبر 2a11 و بررسی بیان آن است. پس از استخراج dna ژنومی از گیاه گوجه­فرنگی، پیشبر 2a11 با استفا...

2017
Yongjie Feng Yaoyao Lu Yinghua Wang Longxian Zhang Yurong Yang

BACKGROUND The parasites Toxoplasma gondii (T. gondii) and Neospora caninum (N. caninum) are globally distributed; they infect warm-blooded animals, including many avian species. The aim of this study was to evaluate the presence of these parasites in ostriches from central China. In total, 402 ostrich (Struthio camelus) samples (293 hearts, 77 brains, and 32 serum) from slaughterhouses of the ...

Journal: :Journal of Immunology 2023

Abstract Objective: Interferon-γ (IFN-γ) is a key cytokine regulating the development of atherosclerosis, but little known regarding phenotype and regulation T cells producing IFN-γ in plaques. Methods: To identify characterize IFN-γ-producing we utilized IFN-γ-YFP Nur77-GFP reporter mice crossed onto an atherosclerotic background (Apoe−/−IFN-γ YFP/YFP; Apoe−/−Nur77GFP/wt), adoptive transfer tr...

2014
Monica Gori Giulio Sandini Cristina Martinoli David C. Burr

Several studies have demonstrated enhanced auditory processing in the blind, suggesting that they compensate their visual impairment in part with greater sensitivity of the other senses. However, several physiological studies show that early visual deprivation can impact negatively on auditory spatial localization. Here we report for the first time severely impaired auditory localization in the...

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