نتایج جستجو برای: 25ohd

تعداد نتایج: 432  

Journal: :Biology of reproduction 2009
N Liu A T Kaplan J Low L Nguyen G Y Liu O Equils M Hewison

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D), is a potent inducer of the antimicrobial protein cathelicidin, CAMP (LL37). In macrophages this response is dependent on intracrine synthesis of 1,25(OH)(2)D from precursor 25-hydroxyvitamin D (25OHD), catalyzed by the enzyme 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). In view of the fact that trophoblastic cells also e...

Journal: :Public health nutrition 2012
Maryam A Al-Ghamdi Susan A Lanham-New Jalal A Kahn

OBJECTIVE Few data exist looking at vitamin D status and bone health in school-aged boys and girls from Saudi Arabia. The present study aimed to determine the extent of poor vitamin D status in school boys and girls aged 6-18 years and to examine if there was any difference in status with age, physical activity and veiling and concomitant effects on bone. DESIGN Cross-sectional study. SETTI...

Journal: :European review for medical and pharmacological sciences 2013
M R Pinzone M Di Rosa B M Celesia F Condorelli M Malaguarnera G Madeddu F Martellotta D Castronuovo M Gussio C Coco F Palermo S Cosentino B Cacopardo G Nunnari

AIM Vitamin D deficiency is very common among HIV-infected subjects. We cross-sectionally evaluated the prevalence and risk factors for hypovitaminosis D in 91 HIV-infected Italian patients. PATIENTS AND METHODS We studied in a cohort of 91 HIV-infected Italian patients the metabolism of Vitamin D by evaluating the in vitro expression of CYP27B1, CYP24A1 and vitamin D receptor (VDR) by monocy...

2014
Mir Sadat-Ali Dalal A. Bubshait Haifa A. Al-Turki Dakheel A. Al-Dakheel Wissam S. Al-Olayani

BACKGROUND AND OBJECTIVE The purpose of the present study is to explore the assessment if the transdermal delivery of vitamin D is feasible. METHODS In 50 female Medical students, this study was conducted. Age, weight and height was taken, a detailed history and clinical examination was performed. Blood was drawn for 25 Hydroxy Vitamin D3 (25OHD) level. Two women had >30 ng/mL of 25OHD and wa...

Journal: :Molecular pharmacology 2012
Zhican Wang Yvonne S Lin Xi Emily Zheng Tauri Senn Takanori Hashizume Michele Scian Leslie J Dickmann Sidney D Nelson Thomas A Baillie Mary F Hebert David Blough Connie L Davis Kenneth E Thummel

Vitamin D(3) is critical for the regulation of calcium and phosphate homeostasis. In some individuals, mineral homeostasis can be disrupted by long-term therapy with certain antiepileptic drugs and the antimicrobial agent rifampin, resulting in drug-induced osteomalacia, which is attributed to vitamin D deficiency. We now report a novel CYP3A4-dependent pathway, the 4-hydroxylation of 25-hydrox...

Journal: :Neurology 2011
Helmut H Leitner

OBJECTIVE Higher latitude, lower ultraviolet exposure, and lower serum 25-hydroxyvitamin D (25OHD) correlate with higher multiple sclerosis (MS) prevalence, relapse rate, and mortality. We therefore evaluated the effects of high-dose vitamin D2 (D2) in MS. METHODS Adults with clinically active relapsing-remitting MS (RRMS) were randomized to 6 months' double-blind placebo-controlled high-dose...

2017
J B Ernst S Prokop U Fuchs J Dreier J Kuhn C Knabbe H K Berthold S Pilz I Gouni-Berthold J F Gummert J Börgermann A Zittermann

BACKGROUND Low 25-hydroxyvitamin D (25OHD) levels (< 75 nmol/l) are inversely associated with anemia prevalence. Since anemia and low 25OHD levels are common in patients with heart failure (HF), we aimed to investigate whether vitamin D supplementation can reduce anemia prevalence in advanced HF. METHODS EVITA (Effect of Vitamin D on Mortality in Heart Failure) is a randomized, placebo-contro...

2014
In Hyuk Chung Hae Jung Kim Sochung Chung Eun-Gyong Yoo

PURPOSE This study was performed to investigate the relationship between serum vitamin D and parathyroid hormone (PTH) levels as well as to describe the prevalence and the risk factors of vitamin D deficiency (VDD) in Korean children. METHODS Participants were 1,212 children aged 4 to 15 years, who visited Bundang CHA Medical Center (located at 37°N) between March 2012 and February 2013. Over...

2010
Lars Rejnmark Peter Vestergaard Lene Heickendorff Leif Mosekilde

Objectives. Statin drugs act as inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase enzyme early in the mevalonate pathway, thereby reducing the endogenous cholesterol synthesis. In recent studies, it has been suggested from epidemiological data that statins also may improve vitamin D status, as measured by increased plasma 25-hydroxyvitamin D (25OHD) levels. We now repor...

Journal: :Saudi medical journal 2011
Mahmood D Al-Mendalawi Bassam Bin-Abbas

OBJECTIVE To assess the prevalence of vitamin D deficiency in type 1 diabetic (T1DM) children. METHODS In this prospective cross-sectional study, we included 100 Saudi children with T1DM attending the Pediatric Endocrinology and Diabetes Clinics, and 100 healthy controls from the Department of Pediatrics, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia from June to September 2010. W...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید