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s / Porto Biomed. J. 2017;2(5):176–246 221 of PT2020, to INNOVMAR (NORTE-01-0145-FEDER-000035, NOVELMAR), supported by NORTE 2020, under PORTUGAL 2020, through ERDF. To Dr. S Cravo for technical assistance.
s / Porto Biomed. J. 2017;2(5):176–246 221 of PT2020, to INNOVMAR (NORTE-01-0145-FEDER-000035, NOVELMAR), supported by NORTE 2020, under PORTUGAL 2020, through ERDF. To Dr. S Cravo for technical assistance.
246 words 41 Article: 3 487 words (excluding abstract, references, figures and tables) 42 43 on Jauary 7, 2018 by gest ht://aem .sm .rg/ D ow nladed fom
Alterations of the TP53 tumor suppressor gene occur in ~30% of primary glioblastoma (GBM) with a high frequency of missense mutations associated with the acquisition of oncogenic "gain-of-function" (GOF) mutant (mut)p53 activities. PRIMA-1MET/APR-246, emerged as a promising compound to rescue wild-type (wt)p53 function in different cancer types. Previous studies suggested the role of wtp53 in t...
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