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A ccumulating research suggests that low 25-hydroxyv i t amin D3 [25(OH)D] concentrations may be inversely associated with type 2 diabetes (1–3), metabolic syndrome (4,5), insulin resistance (6), and cardiovascular disease (CVD) (7). Much remains to be learned, however, about the relationships between vitamin D status, metabolic syndrome, and CVD. Furthermore, the published data in humans argui...
The discovery that the absorption bands at 293, 281-5 and 271 m,u. (Heilbron, Kamm & Morton, 1926, 1927) present in fractions obtained in the recrystallization of cholesterol were shown very strongly by ergosterol (Rosenheim & Webster, 1927) focused interest on the latter and culminated in the isolation ofcalciferol (vitamin D2). Some time later it was recognized that 7-dehydrocholesterol was a...
BACKGROUND Multiple sclerosis (MS) is a common disease of the central nervous system and a major cause of disability amongst young adults. Genome-wide association studies have identified many novel susceptibility loci including rs2248359. We hypothesized that genotypes of this locus could increase the risk of MS by regulating expression of neighboring gene, CYP24A1 which encodes the enzyme resp...
BACKGROUND Experimental evidence has demonstrated an antineoplastic role for vitamin D in the colon, and higher circulating 25-hydroxyvitamin D [25(OH)D] levels are consistently associated with a lower risk of colorectal cancer. Genome-wide association studies have identified loci associated with levels of circulating 25(OH)D. The identified single-nucleotide polymorphisms (SNPs) from four gene...
Given a smooth prime Fano threefold X of genus 7 we consider its homologically projectively dual curve Γ and the natural integral functor Φ : D(X) → D(Γ). We prove that, for d ≥ 6, Φ gives a birational map from a component of the moduli scheme MX(2, 1, d) of rank 2 stable sheaves on X with c1 = 1, c2 = d to a generically smooth (2 d − 9)-dimensional component of the BrillNoether variety W 2d−11...
D. V. and Spector, T. D. (1996) Br. J. Kheumatol. 35, 12991304 20 Hart, D. J., Mootoosamy, I . , Doyle, D. V. and Spector, T. D. (1994) Ann. Rheum. Dis. 53, 158-1 62 21 Dequeker, J. and Johnell, 0. (1995) Bone 14, S5 I -S56 22 Nevitt, M. C., Lane, N. E., Scott, J. E., IIochherg, M. C., Pressman, A. R., Genant, H. K. and Cummings, S. R. (1995) Arthritis Rheum. 38, 907-91 6 23 Dequeker, J. (1997)...
BACKGROUND HIV infection and antiretroviral therapy (ART) may create unique risk factors for vitamin D insufficiency, including alterations of vitamin D metabolism by ART. We prospectively compared demographic and clinical parameters between vitamin D sufficient and insufficient HIV-infected (HIV+) adults, and assessed changes in these parameters among insufficient participants following standa...
The capability of the spatially-distributed, physically-based, rainfall-runoff modelling system, MIKE SHE, to simulate the hydrological behaviour of the natural and drained parts of the North Kent Grazing Marshes, UK, is investigated. The MIKE SHE code is applied to Bells Creek, a small, underdrained, agricultural catchment located within the marshes. The model is used to both provide insights ...
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