vitamin d3 has a role in many autoimmune diseases and appears to play a function in controlling rheumatoid arthritis (ra). the aim of this study is to evaluate the relationship between serum level of vitamin d and ra disease activity score. the serum level of vitamin d in 75 ra patients referred to the rheumatology clinic of rasoul-akram hospital was measured. patients were classified into low,...

Rheumatoid arthritis (RA) is a chronic disease, the etiology of which has yet to be clarified, which causes activation of proinflammatory pathways that bring about joint and systemic inflammation. In recent years, the pathophysiology of CNS involvement that can occur in RA has attracted a great deal of attention. Emphasis has focused on the possibility that CNS involvement occurs due to bl...

leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. leptin and itsreceptor (ob-r) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. the goal of this study was determination of the presence of leptin receptor mrna in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

in  this  study  we  determined  the  frequency,  sensitivity  and  specificity  of  anti  cyclic citrullinated peptides (anti-ccp) igg antibody, total rheumatoid factor (rf-t), and rf isotypes in iranian patients with rheumatoid arthritis (ra) and their association with age, clinical and serological parameters. anti-ccp and rf-t and rf isotypes level were measured in 418 patients and 399 healt...

Objective(s): MicroRNA-21 (miR21) is aberrantly elevated in rheumatoid arthritis (RA) patients, the significance of this microRNA in RA pathogenesis and treatment, however, has not been investigated. In this study, by using RA-derived fibroblast-like synoviocyte (FLS) cells as a model, we investigated the effect and corresponding mechanism of miR21 inhibition on FLSs invasion. Materials and Met...