BACKGROUND Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). METHODS Eighty-three UTUC patients participated in this study. All of them provided cancer tissue s...

Oxidative stress induces endothelial cell apoptosis and promotes atherosclerosis development. MicroRNA-210 (miR-210) is linked with apoptosis in different cell types. This study aimed to investigate the role of miR-210 in human umbilical vein endothelial cells (HUVECs) under oxidative stress and to determine the underlying mechanism. HUVECs were treated with different concentrations of hydrogen...

MiR-210 is up-regulated in multiple cancer types but its function is disputable and further investigation is necessary. Using a bioinformatics approach, we identified the putative target genes of miR-210 in hypoxia-induced CNE cells from genome-wide scale. Two functional gene groups related to cell cycle and RNA processing were recognized as the major targets of miR-210. Here, we investigated t...

The feasibility of disrupting a tumor's vascular structure using (210)Po microspheres is investigated using standard ion and photon absorbed dose methodologies. Calculated absorbed dose profiles for (210)Po alpha particles are sufficient to disrupt a tumor's arteriole structure while minimizing the dose outside the blood vessel wall. (210)Po photons contribute minimal dose to healthy tissue. Th...

OBJECTIVES To evaluate if inexpensive Stepping Meters are valid in counting steps in adults in free living conditions. METHODS For six days, 35 healthy volunteers wore a criterion Yamax Digiwalker and five Stepping Meters every day until all 973 pedometers had been tested. Steps were recorded daily, and the differences between counts from the Digiwalker and the Stepping Meter were expressed a...

Smart Meters belong to the Advanced Metering Infrastructure (AMI) and allow customers to monitor locally and remotely the current usage of energy. Providers query Smart Meters for billing purpose or to establish the amount of energy needed by houses. However, reading details sent from smart meters to the energy provider can be used to violate customers’ privacy. In this paper, our contribution ...

Aims: The Nova StatStrip blood glucose monitoring system was evaluated for precision, accuracy, and interferences from haematocrit and maltose. It was also compared against three other meters and two reference methods. Methods: Heparinised whole blood samples were analysed on the meters. These results were compared with whole blood samples analysed on the Radiometer ABL835 for the interference ...

There is a need for better prognostication in prostate cancer (PC). "The micromanager of hypoxia", microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy p...