D.H. Lehmer found a quadratic polynomial such that 326 is a primitive root for the first 206 primes represented by this polynomial. It is shown that this is related to the class number one problem and prime producing quadratics. More impressive examples in the same spirit are given using recent results on prime producing quadratics. Y. Gallot holds the current record in which 206 is being repla...

A new descriptive index, the HHI (hypocalcification-hypoplasia index), is described for comparing enamel defects in groups of people. The index was used in a study completed in 1986, in which 1251 11-year-old children from different ethnic groups resident in South Africa were examined: 210 rural black, 203 urban black, 206 urban colored, 426 urban Indian, and 206 urban white. The index can be u...

Corresponding author: Keith R. Jerome, MD, PhD Fred Hutchinson Cancer Research Center 1100 Fairview Avenue N, D3-100 Seattle, Washington 98109 Telephone: +1 206 667-6793 Facsimile: +1 206 667-4411 E-mail: [email protected] AC EP TE D Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.01230-06 JCM A...

Synthetic peptides are widely used in immunological research as epitopes to stimulate their cognate T cells. These preparations are never completely pure, but trace contaminants are commonly revealed by mass spectrometry quality controls. In an effort to characterize novel major histocompatibility complex (MHC) Class I-restricted β-cell epitopes in non-obese diabetic (NOD) mice, we identified i...

D.H. Lehmer found a quadratic polynomial such that 326 is a primitive root for the first 206 primes represented by this polynomial. It is shown that this is related to the class number one problem and prime producing quadratics. More impressive examples in the same spirit are given using recent results on prime producing quadratics. Y. Gallot holds the current record in which 206 is being repla...

epidemiological research. ∗To whom correspondence should be addressed: Department of Biostatistics, University of Washington, Seattle WA 98195, tel: 206-616-6846, fax: 206-543-3286, email: [email protected] †Supported by the United States Environmental Protection Agency through R831697 and Assistance Agreement CR-83407101 and by the National Institute of Environmental Health Sciences thr...

BACKGROUND Abnormal expression of connexin 43 (Cx43) has been reported to play an important role in the development of conotrunccal anomalies. However, less is known about the underlying reason for its abnormal expression. MicroRNAs (miRNAs), as an important part of gene expression regulation, have been implicated in some cardiac diseases. This study aimed to investigate the expression of Cx43 ...

MicroRNA (miRNA) maturation is regulated by interaction of particular miRNA precursors with specific RNA-binding proteins. Following their biogenesis, mature miRNAs are incorporated into the RNA-induced silencing complex (RISC) where they interact with mRNAs to negatively regulate protein production. However, little is known about how mature miRNAs are regulated at the level of their activity. ...

Differentiation of T helper 17 cells (Th17) is a multistep process that involves the cytokines IL-6, TGF-β, and IL-23 as well as IL-1β, IL-21, and TNF-α. Thereby, robust induction of the capacity to produce IL-17 involves epigenetic modifications of the syntenic Il17a/f locus. Using inbred mouse strains, we identified co-regulation of gene transcription at the Il17a/f locus with the nearby micr...