two-dimensional electrophoresis (2-d electrophoresis) is a powerful and extensively used method for analysis of complex protein mixtures extracted from cells, tissue, or other biological samples such as helminth parasites including, f. hepatica. each spot on the resulting two-dimensional collection corresponds to a single protein species in the sample. this study was carried out to detect of gs...

Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), ...

A tissue-specific distribution of the various vitamin E forms, tocotrienols and tocopherols, has been found, suggesting that these forms have unique roles in cellular functions. A sensitive procedure is described for the simultaneous determination of individual tocopherols, tocotrienols, ubiquinols, and ubiquinones using gradient high pressure liquid chromatography (HPLC) and electrochemical de...

Silver-cobalt nanoparticles are used in medicine. In this study, the effects of silver-cobalt nanoparticles on functional tests and liver tissue changes in adult male rats were investigated. 28 adult male Wistar rats weighing 180-220 g were divided into 4 groups of 7. Control group, Experimental group1 received 25mg / kg of silver-cobalt nanoparticles (AgCo NPs) in which silver nanoparticle (Ag...

Background: Zinc oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were ...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with oxidative stress, inflammation, and decrease in peroxisome proliferator-activated receptor alpha (PPAR-α) expression. Nitrochalcone is effective ingredient of chalcones with anti-inflammatory, anti-cancer and anti-hyperglycemic properties. This study examined the effect of intraperitoneal (IP) administration of nitrochal...

In poultry, the liver is the main organ for the synthesis of triglycerides (TG) and their secretion into the plasma. Secretion of TGs from the liver and their storage in adipose tissue of the abdominal cavity reduces the meat yield. There are controversial reports about the effects of garlic on the levels of TG in the serum and liver of poultry. In this study, different diets that contained var...

Rats from the NZR/Mh strain have a genetically-determined deficiency of phosphorylase b kinase activity in the liver which in homozygotes &d/g@ produces a poor activation of glycogen phosphorylase and very high liver glycogen concentrations [I]. They also have low active glycogen synthase activities [l] and previous studies on liver homogenates have shown an inhibition of glycogen synthasephosp...