The pyridone fragment in the ligand [2, 2’-bipyridin]-6(1H)-one (bipy-6-OH) enables oxidative Heck reaction of simple arenes with oxygen as sole oxidant and no redox mediator. Arenes either electron-donating or electron-withdrawing groups can be functionalized this way. Experimental data on toluene model arene shows that C−H activation step is turnover limiting structure crucial to facilitate r...

In the absence of alternative technology of hybrid development, chemical induction of male sterility-mediated technology based on chemical hybridising agents (CHAs) holds immense potential. 5-Carbethoxy-N-aryl-4,6-dimethyl-1,2dihydropyrid-2-ones have been synthesized by the condensation between substituted anilines with ethyl isodehydracetate and evaluated as chemical hybridising agents on whea...

Research interests: Asymmetric catalysis for organic synthesis, including chiral diaminocarbene ligands and VHOIɅDVVHPEOHGGLQXFOHDU catalysts; development of VPDOOPROHFXOHDQWLɅFDQFHU agents; and total synthesis of complex molecules with interesting biological activities. Abstract Novel chiral Co-salen catalysts capable of self-assembly through hydrogen bonding have been developed. First, a self...

To investigate the influence of the pyrimidine 2-keto group on selection of nucleotides for incorporation into DNA by polymerases, we have prepared two C nucleoside triphosphates that are analogues of dCTP and dTTP, namely 2-amino-5-(2'-deoxy-beta-d-ribofuranosyl)pyridine-5'-triphosphate (d*CTP) and 5-(2'-deoxy- beta-d-ribofuranosyl)-3-methyl-2-pyridone-5'-triphosphate (d*TTP) respectively. Bot...