The synthesis and isolation of 6-phenylethynyl picolinic acid (PEPCA; IUPAC name: 6-(2-phenylethynyl)pyridine-2-carboxylic acid) was first demonstrated when Acinetobacter sp. strain F4 was used to biotransform diphenylacetylene to the ring-fission product that underwent facile ring closure to form PEPCA in the presence of ammonium ions. Here, the structure and properties of PEPCA were confirmed...

The responses of female noninbred mouse urinary bladder ornithine decarboxylase (EC 4.1.1.17) (ODC) and S-adenosylu-methionine decarboxylase (EC 4.1.1.50) (SAMD) activities to L-tryptophan feeding and to topical intraurethral administration of L-tryptophan and some of its urinary metabolites were stud ied. Mice fed a diet containing 1% L-tryptophan demonstrated significant increases in vesical ...

The responses of female noninbred mouse urinary bladder ornithine decarboxylase (EC 4.1.1.17) (ODC) and S-adenosylu-methionine decarboxylase (EC 4.1.1.50) (SAMD) activities to L-tryptophan feeding and to topical intraurethral administration of L-tryptophan and some of its urinary metabolites were stud ied. Mice fed a diet containing 1% L-tryptophan demonstrated significant increases in vesical ...

Diabetic foot ulcerations could result in serious consequences such as amputations. The up-regulation of matrix metalloproteinases and down-regulation of TIMP1 were remarked as distinctive biological characteristics in the diabetic dermal fibroblast. The current study was performed in order to clarify the effect of high glucose on formation of diabetic dermal fibroblast cell. In addition, the e...