Fe(0 0 1) thin films (70 ( A) with Fe(7.2 ( A) tracer layers at the interface were epitaxially grown on GaAs(4 6) surfaces. Magneto-optic Kerr effect and Ferromagnetic resonance measurements indicate a dominant 2-fold in-plane magnetic anisotropy (easy axis along [1 1 0]) superimposed to a 4-fold anisotropy, and small coercivity (B10Oe). M . ossbauer (CEMS) measurements indicate no magnetic ‘‘d...

We recently showed that acute oxidant-related lung injury (ALI) in rats after application of 2-chloroethyl ethyl sulfide (CEES) is attenuated by the airway instillation of antioxidants. We investigated whether intratracheal administration of antioxidant-containing liposomes immediately after instillation of CEES would attenuate short-term as well as long-term (fibrotic) effects of CEES-induced ...

Sulfur mustards (SMs) have been used as warfare agents since World War I and still pose a significant threat against civilian and military personnel. SM exposure can cause significant blistering of the skin, respiratory injury, and fibrosis. No antidote currently exists for SM exposure, but recent studies, using the SM analog 2-chloroethyl ethyl sulfide (CEES), have focused on the ability of an...

A class of heterogeneous catalysts based on commercial bentonite from natural origin, containing at least 80 wt% of montmorillonite clay, was designed to transform selectively and under mild conditions toxic organosulfur and organophosphorus chemical warfare agents into non-noxious products with a reduced impact on health and environment. The bentonite from the natural origin was modified by in...

The DNA sequenceselectivitiesof guanine-N7alkylation producedby three chloroethylating antitumor agents, I-(2-chloroethyl)-3-(cis-2-hy droxy)cyclohexyl-l-nitrosourea(cis-2-OH CCNU), 2-chloroethyl(meth ylsulfonyl)methanesulfonate,and 8-carhamoyl-3-(2-chloroethyl)imidazo 15,l-dl-l,2,3,5-tetrazin-4(3H)-one (mitozolomide), were examined using a modification of the Maxam and Gilbert sequencing techn...

DNA is a major cellular target of the vesicant chemical warfare agent sulfur mustard (SM, bis-(2-chloroethyl) sulfide). Others and we have proposed a possible role of apoptosis in SM vesication. Our results suggest that in SM-exposed human epidermal keratinocytes (HEK), DNA damage, DNA repair, and apoptosis may be interdependent. In HEK, SM causes cell death accompanied by caspase-3 activation ...

Sulfur mustard or mustard gas (HD) and its monofunctional analog, 2-chloroethyl ethyl sulfide (CEES), or "half-mustard gas," are alkylating agents that induce DNA damage, oxidative stress, and inflammation. HD/CEES are rapidly absorbed in the skin causing extensive injury. We hypothesize that antioxidant liposomes that deliver both water-soluble and lipid-soluble antioxidants protect skin cells...

The chemical warfare agent analog, 2-chloroethyl ethyl sulfide, known as 'half-mustard gas' (HMG), is less toxic and less of an environmental hazard than the full molecule and has been shown to produce an acute lung injury in rats when instilled via intrapulmonary injection. This injury is characterized by massive, localized hemorrhage and edema into the alveolar compartment and can be quantita...

RATIONALE Sulfur mustard (SM) is a frequently used chemical warfare agent, even in modern history. SM inhalation causes significant respiratory tract injury, with early complications due to airway obstructive bronchial casts, akin to those seen after smoke inhalation and in single-ventricle physiology. This process with SM is poorly understood because animal models are unavailable. OBJECTIVES...