The electronic and molecular structure of 2,6-bis{/V-(2-hydroxyphenyl)iminomethyl}-4methylphenol (hpimp) is clarified from the measurements of electronic absorption and 'H NMR spectra in various solvents and an X-ray diffraction analysis, together with MO calcula­ tions. Electronic absorption bands of hpimp are at 422, 397.9, 359, 341, 294.3, 265.8, and 224 nm in the non-polar solvent cyclohexa...

Cisplatin, doxorubicin, hydroxycamptothecin, leucovorin, vincristine and 5-fluorouracil resistance of cancer cells are associated with the activities C-Jun N-Terminal Kinase 1 (JNK1). Inhibition JNK1 by pharmacological agents could be a beneficial attempt for reversing chemoresistance various cells. However, there is no FDA-approved JNK inhibitor safe use in clinics today’s clinics. In this stu...

2-((3-(Ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino)-4-(4-methoxyphenyl)-4-oxobut-2-enoate has been synthesized by the reaction of ethyl (E)-2-((5-(4-methoxyphenyl)-2-oxofuran-3(2H)-ylidene)amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate or 2-((3-(ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino)-4-(4-methoxyphenyl)-4-oxobut-2-enoate with potassium tert-bu...

Thymol (2-isopropyl-5-methylphenol), and carvacrol (5-isopropyl-2-methylphenol) are the main components of the essential oils of some Laminaceae,Verbenaceae and Ranunculaceae members such as oregano, thyme, savory, etc. The formation of thymol and carvacrol is thought to involve hydroxylation of γ-terpinene and p-cymene precursors. They are produced by the plant species as a chemical defe...

In the title compound, C11H10BrNO3, two independent mol-ecules (A and B) crystallize in the asymmetric unit. The dihedral angles between the mean planes of the 4-bromo-phenyl ring and amide group are 24.8 (7) in mol-ecule A and 77.1 (6)° in mol-ecule B. The mean plane of the methyl-idene group is further inclined by 75.6 (4) in mol-ecule A and 72.5 (6)° in mol-ecule B from that of the amide gro...

In the title compound, C13H13NO4, the N-C(=O) bond length of 1.354 (2) Å is indicative of amide-type resonance. The dihedral angle between the mean planes of the benzene ring and oxo-amine group is 36.4 (3)°, while the mean plane of the 2-methyl-idene group is inclined by 84.2 (01)° from that of the oxo-amine group. In the crystal, classical O-H⋯O hydrogen bonds formed by the carb-oxy-lic acid ...