Abstract: Introduction: Diabetes Mellitus is a disorder of metabolism described by high glucose levels. The kills larger number individuals consistently than malignant growth and AIDS combined. Presently available drugs have several drawbacks forcing to withdraw from treatment. potent side effect i.e., hepatotoxicity cardiovascular toxicity limits the use thiazolidine-2,4-dione derivative as sa...

The molecular mechanisms of three intramolecular rearrangements (I, the rearrangement allyloxycycloheptatriene to yield tricyclic ketones; II, cycloaddition a nitrone-alkene render two isoxazolidines; and III, decomposition N-carbamoyl-L-proline in tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione plus water, or tetrahydro-1H,3H-pyrrolo[1,2-c]oxazole-1,3-dione ammonia) have been studied by me...

1. Indene has been administered to rabbits by stomach tube, and fractionation of ether extracts of the urine has yielded optically active c8and tran8-indane-1:2-diol in a total amount corresponding to about 5% of the dose. Acid treatment of the urine, either before or after ether extraction, yielded indan-2-one in amounts corresponding to about 25% of the dose of indene. 2. The same two diols h...

Ferrocenoindenes display planar chirality and thus represent valuable ligands for asymmetric catalysis. Here, we report on the synthesis of novel 3-(1,1dibromomethylene)ferroceno[1,2-a]indene, (Z)-3-(1-bromomethylene)-6-iodoferroceno[1,2a]indene, and benzo[5,6-f]ferroceno[2,3,a]inden-1-one. Any application-oriented design of chiral catalysts requires fundamental knowledge about the ligands invo...

Some new Zn(II) and Cu(II) complexes [Cu(L1)(OAc)2]∙H2O, [Cu(L1)(NO3)H2O]∙NO3∙3.5H2O, [Zn(L1)(NO3)2]∙4.5H2O, [Zn(L1)(OAc)2(H2O)2]∙3H2O, [Cu2(L2)(OAc)4]∙2H2O∙2DMF, [Cu(L2)2]∙2NO3∙1.5DMF∙H2O, [Zn(L2)2(NO3)2]∙DMF and [Zn2(L2)(OAc)4(H2O)4]∙5H2O; L1 = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L2 = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized ...

Lumazine synthase and riboflavin synthase catalyze the last two steps in the biosynthesis of riboflavin. To obtain structural and mechanistic probes of these two enzymes, as well as inhibitors of potential value as antibiotics, a sulfur analogue of the pyrimidine substrate of the lumazine synthase-catalyzed reaction and product of the riboflavin synthase-catalyzed reaction was designed. Facile ...