Objective (s): Cerium oxide nanoparticles nanoceria (CeNPs) is a novel nanoparticle that has great potential for the treatment of various diseases. This study aimed to investigate the effects of CeNPs on oxidative stress biomarkers in the liver of male rats. Materials and Methods: Twenty-four male Wistar rats were equally distributed into 4 groups (n=6/each). The first group was controlled and ...

The objective of this study was to determine whether α-adrenergic receptors are involved in the contractile activity of neuropeptide Y (NPY) in the porcine isolated ovarian artery collected from immature pigs and from the animals on day 1–5, 8–13 and 17–20 of the estrous cycle. NPY increased (P < 0.05) blood pressure in preparations collected form the immature and mature pigs. NPY administratio...

The smoothness of the solutions of 1D scalar conservation laws is inves11 tigated and it is shown that if the initial value has smoothness of order α in Lq with α > 1 and q = 1/α, this smoothness is preserved at any time t > 0 for the graph of the 13 solution viewed as a function in a suitably rotated coordinate system. The precise notion of smoothness is expressed in terms of a scale of Besov ...

Under the assumption of the Riemann hypothesis, the Linear Independence hypothesis, and a bound on negative discrete moments of the Riemann zeta function, we prove the existence of a limiting logarithmic distribution of the normalisation of the weighted sum of the Liouville function, Lα(x) = ∑ n≤x λ(n)/n α, for 0 ≤ α < 1/2. Using this, we conditionally show that these weighted sums have a negat...

In mammals, a low molecular mass protein (17-20 KDa) reported from the pheromone sources such as urine, saliva, glandular secretion, etc., as ligand-carrier (pheromone carrier) has been associated with chemo-communication. Since the preorbital gland post is one of the major pheromone sources in Indian Blackbuck, an endangered species, we assumed that it possibly contains low molecular mass prot...

BACKGROUND Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The inflammatory disorders associated to HTLV-1 are mediated by different proinflammatory cytokines as IL-1α, IL-6, TNF-α. The release and the role of IL-17 is still debated. Aims ...

BACKGROUND/AIM Gemcitabine (GEM) has antiproliferative effects on lymphocytes, which are potent pathogenic actors of rheumatoid arthritis (RA). The aim of the study was to investigate the therapeutic potential of GEM on collagen-induced arthritis (CIA). MATERIALS AND METHODS Arthritis was induced by the intradermal injection of chicken type II collagen with incomplete Freund's adjuvant into a...

Nail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels of TNF-α, IL-12/23 p40, and IL-17 in psoriatic patients with and without nail involvement. 52 consecutively selected...

OBJECTIVES To study effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on RANKL signaling pathway and pathway-associated cytokines in patients with rheumatoid arthritis (RA). METHODS Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), IFN- γ , IL-6, TNF- α , IL-17, and IL-4 were examined in 54 patients with incipient RA using a cytometric bead array (CBA) or an ...

Objective. To determine whether immunological serum markers IFN-γ, IL-4, IL-17, IL-23, IL-6, TNF-α, and IL-10 are elevated or decreased in patients compared with healthy controls. Methods. A complete search of the literature on this topic within the past 30 years was conducted across seven databases. Seventeen studies including 768 individuals were identified. Differences in serum marker levels...