BACKGROUND The aim of the present retrospective study was to analyze clinical outcome and risk factors associated with treatment outcomes according to KRAS status in patient with metastatic colorectal cancer (mCRC) treated with bevacizumab (bev) plus chemotherapy in the first-line setting. METHODS We performed observational study on 1622 patients with mCRC treated with bev plus oxaliplatin- o...

Wastewater samples collected from ten wastewater facilities across the US were analyzed to determine the occurrence of indigenous Cryptosporidium oocysts using methods based on modifications of USEPA Method 1622. Wastewater facilities participating in this study ranged in size from 0.6 to 193 mgd average daily flow. A total of 289 wastewater samples were analyzed over a 15-month period. ColorSe...

Daily feed intake (DFI) is an important consideration for improving feed efficiency, but measurements using electronic feeder systems contain many missing and incorrect values. Therefore, we evaluated three methods for correcting missing DFI data (quadratic, orthogonal polynomial, and locally weighted (Loess) regression equations) and assessed the effects of these missing values on the genetic ...

Previous results regarding the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in gastric cancer are conflicting, and full analysis of other blood test parameters are lacking. We therefore examined the associations between various blood test parameters and prognosis in 3243 gastric cancer patients randomly divided into training (n=1621) and va...

INTRODUCTION AND OBJECTIVES To assess the impact of a program integrating cardiology and primary care in clinical practice, compared with usual care. The integrated care consists of a hospital cardiologist in each primary care clinic, shared clinical history, joint practice guidelines, consultation sessions, and other coordinating tools. METHODS Observational, cross-sectional study of 2 serie...

Klotsche J, TonnT, Dimmeler S, Zeiher AM. Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial. JAMA 2013;309:1622–1631. 12. Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E. Intracoronary cardio...

Background: Because of changing world demographics, the elderly population is steadily increasing. Few studies have assessed the prevalence of atopy and allergic diseases in elderly persons with objective measures. The aim of this paper is to describe the prevalence of atopy, self-reported allergic rhinitis and doctor’s diagnosed asthma in persons over the age of 60 in Switzerland. Methods: The...

The aim of this study was to determine the effects different pre-sowing operations on abundance and composition total soil fauna in soybean cultivation, with special attention carabids as biological indicators agroecosystem quality. conducted central Croatia six activities (cover crop, mulching, ploughing, glyphosate, fertiliser removal, conventional tillage). Pitfall traps were used collect Ap...

El objetivo del estudio fue estimar los componentes de varianzas, la heredabilidad y correlaciones genéticas fenotípicas rasgos productivos las líneas cuyes Saños Mantaro, desarrolladas en Estación Experimental Agraria Santa Ana, Junín (Perú). Se calculó además consanguinidad dos líneas. analizaron registros desde 2017 a 2020. evaluaron peso al nacimiento (PN), destete (PD), semana 4 (P4), 8 (P...