نتایج جستجو برای: 15 benzodiazepine

تعداد نتایج: 501261  

Journal: :JPMA. The Journal of the Pakistan Medical Association 2013
Muhammad Junaid Patel Syed Ahmer Faheem Khan Abdullah Waqar Ahmed Qureshi Muhammad Farrukh Shehzad Sania Muzaffar

OBJECTIVE To estimate the prevalence of Benzodiazepine use in the outpatient setting of general medicine clinics at a single tertiary care centre. METHODS The prospective prevalence study was conducted in the outpatient setting of Internal Medicine Clinics at Aga Khan University Hospital, Karachi, from November to December 2009. All subjects were interviewed after informed consent and variabl...

Journal: :Journal of analytical toxicology 2012
Paula Melo M Lourdes Bastos Helena M Teixeira

Benzodiazepine (lorazepam, estazolam, chlordiazepoxide, and ketazolam) stability was studied in postmortem blood, bile, and vitreous humor stored at different temperatures over six months. The influence of NaF, in blood and bile samples, was also investigated. A solid-phase extraction technique was used on all the studied samples, and benzodiazepine quantification was performed by high-performa...

Journal: :JBI database of systematic reviews and implementation reports 2015
Anne Dabrow Woods Renee Giometti Susan M Weeks

BACKGROUND Chronic alcohol consumption is a prevalent issue. Healthcare professionals often discover their patient has an alcohol consumption issue when they are admitted to the hospital and no longer have access to alcohol. The global standard for treating alcohol withdrawal syndrome (AWS) symptoms are benzodiazepines; however this therapy is often inadequate to control symptoms of delirium in...

2007

Until 27 April 2006, the Netherlands Pharmacovigilance Centre Lareb received 7 reports of amenorrhea associated with the use of olanzapine. The time to onset varies from a few weeks to 10 months. The outcome was reported in 3 cases. One patient recovered after drug withdrawal and two patients did not recover; in one patient there was a dose increase to 15 mg once daily. In case D, hyperprolacti...

2011
Lone Baandrup Birgitte Fagerlund Poul Jennum Henrik Lublin Jane L Hansen Per Winkel Christian Gluud Bob Oranje Birte Y Glenthoj

BACKGROUND Treatment of schizophrenia frequently includes prolonged benzodiazepine administration despite a lack of evidence of its use. It is often difficult to discontinue benzodiazepines because of the development of dependence. We aim to assess if melatonin can facilitate the withdrawal of prolonged benzodiazepine administration in patients with schizophrenia. Furthermore, we aim to investi...

Journal: :Japanese journal of pharmacology 1989
S Tokuyama M Takahashi H Kaneto

beta-Carboline-3-carboxylic acid ethyl ester (beta-CCE) dose-dependently potentiated psychological-stress induced analgesia (PSY-SIA), and the effect was reversed by diazepam. Concurrent exposure to PSY stress or concomitant treatment with beta-CCE blocked the development of analgesic tolerance to morphine; the effect of PSY stress was antagonized by diazepam, and that of beta-CCE was reversed ...

Journal: :Archives of emergency medicine 1987
G M Galvin G A Jelinek

Midazolam meleate, a water soluble 1,4 benzodiazepine, was used intravenously in 20 patients suffering seizures, of whom 12 were in status epilepticus. In all cases, midazolam in a dose of 2.5-15 mg rapidly terminated the seizure. There were no complications from the use of midazolam. The causes of the seizures were varied but alcohol-withdrawal seizures were the single largest cause. Thirteen ...

Journal: :Journal of affective disorders 1990
G M Stocks S C Cheetham M R Crompton C L Katona R W Horton

Benzodiazepine binding was measured in amygdala and hippocampus from 19 suicides in whom a firm diagnosis of depression was established retrospectively, and 19 well-matched controls. The number and affinity of benzodiazepine binding sites did not differ significantly between the drug-free or drug-treated suicides and controls.

2007
Jun Song Guofu Shen L. John Greenfield Elizabeth I. Tietz

Modification of glutamatergic synaptic function, a mechanism central to neuronal plasticity, may also mediate long-term drug effects, including dependence and addiction. Benzodiazepine withdrawal results in increased glutamatergic strength, but whether -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors (AMPARs) are functionally and structurally remodeled during benzodiazepine ...

Journal: :Molecular medicine 2013
Sonja M Wojcik Martesa Tantra Beata Stepniak Kwun-Nok M Man Katja Müller-Ribbe Martin Begemann Anes Ju Sergi Papiol Anja Ronnenberg Artem Gurvich Yong Shin Iris Augustin Nils Brose Hannelore Ehrenreich

Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together. Unfortunately, treatment of anxiety disorders still includes benzodiazepines, and patients with an existing comorbid benzodiazepine use disorder or a genetic susceptibility for benzodiazepine use disorder may be at risk of adverse treatment outcomes. The identification of genetic predictors ...

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