Purpose: To evaluate the feasibility of developing a novel mini drug pump for ophthalmic use. Methods: Using principles of microelectromechanical systems engineering, a mini drug pump was fabricated. The pumping mechanism is based on electrolysis and the pump also includes a port for drug refill as well as a check valve to control delivery of the drug. Drug pumps were first tested on the bench-...

1 Information Security Center, State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, P. O. Box 145, Beijing 100876, China 2Key Laboratory of Network and Information Attack and Defence Technology of MOE, Beijing University of Posts and Telecommunications, P. O. Box 145, Beijing 100876, China 3National Engineering Laboratory for Disaster ...

Switching of vascular smooth muscle cells (VSMCs) from a contractile phenotype to an adverse proliferative phenotype is a hallmark of atherosclerosis or vascular restenosis. However, the genetic modulators responsible for this switch have not been fully elucidated in humans nor have they been correlated with clinical abnormalities. This study investigated genetic mechanisms involved in phenotyp...

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and have multiple effects in various tissues including adipose inflammation, a condition characterized by increased local release of the pro-lipolytic cytokine tumor necrosis factor-alpha (TNF-α). Whether miRNAs regulate adipocyte lipolysis is unknown. We set out to determine whether miRNAs affect adipocyte lipolysis in ...

BACKGROUND AND OBJECTIVE MicroRNAs (miRNAs) have been shown to be associated with various physiological and pathological conditions, including inflammation and cardiovascular disease, but little is known about their relationship with the presence of coronary artery disease (CAD) and disease severity. METHODS A total of 195 consecutive subjects who underwent coronary angiography for chest pain...

(+)-S-145 [5-(+)-(Z)-7-[(1R, 2S, 3S, 4S)-3-phenylsulfonylaminobicyclo[2.2.1]hept-2-yl]-heptenoic acid] and its beta-oxidized metabolites [two [bisnor or dihydro (DH)-bisnor] or four (tetranor) carbon-shortened products at the carboxyl side chain] are hydroxylated at the C-5 or C-6 position of the bicyclo ring by microsomal monooxygenases. We investigated the oxidative metabolism of (+)-S-145 an...

Background and objective In an attempt to discover a new biomarker for early diagnosis and prognosis of esophageal squamous cell carcinoma (ESCC), the regulation mechanism of large intergenic non-coding RNA-regulator of reprogramming (lincRNA-ROR) as a microRNA (miRNA) sponge was studied. Patients and methods ROR expression in 91 pairs of ESCC tissue samples and matched adjacent tissues was q...

AMA Rok-Bujko P, Kawecka J. Psychological and functional problems of children adolescents with cerebral palsy from the neurodevelopmental perspective. Pediatria Polska - Polish Journal Paediatrics. 2023;98(2):145-153. doi:10.5114/polp.2023.128854. APA Rok-Bujko, P., & Kawecka, (2023). Paediatrics, 98(2), 145-153. https://doi.org/10.5114/polp.2023.128854 Chicago Paulina, Joanna Kawecka. 2023. "P...