An extended HI cloud (VIRGOHI 21) with an HI mass of ∼ 10 M⊙ and no apparent optical counterpart was recently discovered in the Virgo cluster. In order to understand the origin of physical properties of apparently isolated HI clouds like the VIRGOHI21, we numerically investigate physical properties of tidal HI debris that were formed by galaxy-galaxy interaction in clusters of galaxies. Our hyd...

     It has been reported that in different regions and sowing dates, the response of crops to past climate change is not the same, due to different rates of decrease/increase in each climatic variable at different regions and months of year. This study was aimed to assess the effect of individual versus simultaneous changes in solar radiation (S), precipitation (P) and temperature (T) on rainf...

BACKGROUND IL-1β is an essential factor of inflammation initiation, and it also promotes malignant transformation, indicating its tumorigenic property. We aimed to investigate the correlation between IL-1β and miR-144-3p as well as their prognostic values in LUAD and LUSC patients. RESULTS The IL-1β level in both LUAD and LUSC patients was significantly higher than that of healthy donors (P <...

BACKGROUND MicroRNA (miR) dysregulation is found in Alzheimer disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology. RESULTS miR-144 suppresses ADAM10 expression and is up-regulated by activator protein-1. CONCLUSION miR-144 is a negative regulator of ADAM10 and may be involved in AD pathogenesis. SIGNIFICANCE The first...

Hypoxia-ischemia (HI) is associated with premature birth, and injury during term birth. Many infants experiencing HI later show disruptions of language, with research suggesting that rapid auditory processing (RAP) deficits (i.e., impairment in the ability to discriminate rapidly changing acoustic signals), play a causal role in language problems. We recently bridged these lines of research by ...

BACKGROUND AND PURPOSE Perinatal hypoxia-ischemia (HI) produces acute and prolonged inflammation of the brain. Mast cells (MCs), numerous in the pia and CNS of neonatal rats, can initiate inflammation attributable to preformed mediators. MCs contribute to HI brain damage in the neonatal rat; MC stabilization protects through 48 hours of reperfusion. Here we hypothesize that HI induces early MC ...

Article history:Received 24 June 2008Revised 2 December 2008Accepted 3 December 2008Available online 24 December 2008Hypoxic–ischemic injury (HI) to the neonatal brain results in delayed neuronal death with accompanyinginflammation for days after the initial insult. The aim of this study was to depict delayed neuronal death afterHI using Manganese-enhanced MRI (MEMRI...

The hippocampus is injured in both hypoxia-ischemia (HI) and perinatal iron deficiency that are co-morbidities in infants of diabetic mothers and intrauterine growth restricted infants. We hypothesized that preexisting perinatal iron deficiency predisposes the hippocampus to greater injury when exposed to a relatively mild HI injury. Iron-sufficient and iron-deficient rats (hematocrit 40% lower...

We have previously shown that cycloheximide significantly inhibited apoptosis, and reduced ensuing cerebral infarction in a newborn rat model of cerebral hypoxiaischemia. This study was performed to determine the therapeutic window for cycloheximide therapy. Seven day-old newborn rat pups were subjected to 100 min of 8% oxygen following a unilateral carotid artery ligation, and cycloheximide wa...