This study reports on the development of bio-based hydrophobic coatings for packaging papers through deposition of polyhydroxybutyrate (PHB) particles in combination with nanofibrillated cellulose (NFC) and plant wax. In the first approach, PHB particles in the micrometer range (PHB-MP) were prepared through a phase-separation technique providing internally-nanosized structures. The particles w...

MicroRNA are small, non-coding, single-stranded RNAs that are estimated to regulate ~60% of the human genome. MiRNA profiling of monocyte-to-osteoclast differentiation identified miR-142-3p as a miRNA that is significantly, differentially expressed throughout osteoclastogenesis. Enforced expression of miR-142-3p via transient transfection with miR-142-3p mimic inhibited cell-to-cell contact and...

OBJECTIVE The aim of current study was to assess the association between miR-142-3p expression and the prognosis of patients with cervical cancer. PATIENTS AND METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to assess the expression level of miR-142-3p in cervical cancer tissues and matched normal tissues. Then, statistical analysis was performed to determine ...

The study of crystals of molecular wheels as nanoporous materials is reported. Hyperpolarized (129)Xe NMR spectroscopy has been used to characterize the mode of molecular diffusion and Xe interactions within the supramolecular nanochannels formed upon crystallization of the molecular wheels [Ga(10)(OMe)(20)(O(2)CMe)(10)] and [Ga(18)(pd)(12)(pdH)(12)(O(2)CMe)(6)(NO(3))(6)](NO(3))(6). In agreemen...

Wnt/β-catenin signaling pathway plays essential roles in mammalian development and tissue homeostasis. MicroRNAs (miRNAs) are a class of regulators involved in modulating this pathway. In this study, we screened miRNAs regulating Wnt/β-catenin signaling by using a TopFlash based luciferase reporter. Surprisingly, we found that miR-142 inhibited Wnt/β-catenin signaling, which was inconsistent wi...

MicroRNAs (miRNAs/miRs) serve an important role in the regulation of carcinogenic pathways. RCC is the most prevalent kidney cancer that occurs in adults. miRNAs have gained increasing attention due to their association with RCC tumorigenesis, serving as biomarkers for early detection and progression monitoring, and as potential targets for molecular therapy. Upregulation of miRNA-142-3p has be...

Hematopoietic-specific miR-142 is a critical regulator of various blood cell lineages including CD4 dendritic cells and platelet biogenesis in megakaryocytes. Furthermore, we recently reported that miR-142 is required in order to maintain the biconcave shape of erythrocytes, their structural resilience and lifespan, through a mechanism that involves actin filament homeostasis. Here, we used a m...

miR-142 keeps CD4 DCs in balance ---------------------------------------------------------------------------------------------------------------Gabrielle T. Belz1 1THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH In this issue of Blood, Mildner et al report elucidation of a transcriptome-wide miRNA map for in vivo mononuclear phagocyte populations. Using this approach, they identify that...

Many strategic situations in business, international relations, politics, or war are well approximated by games. A game is a multi-person decision situation, defined by its structure: the players, its “rules” (the order of players’ decisions, their feasible decisions at each point, and the information they have when making them); how players’ decisions determine the outcome; and players’ prefer...