High expression of the proprotein processing enzyme FURIN has been associated with tumor progression and metastasis. A SNP (rs4932178) in the promoter of FURIN has been reported to affect expression in liver, with the T allele resulting in higher expression than the C allele. In this study we have investigated the association of this SNP with prognostic and biological subgroups of colorectal ca...

In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Awan and coworkers1 describe the study of 25 homozygous familial hypercholesterolemic (FH) patients aged 5 to 54 years. Eighteen of the patients had aortic calcification scores 1000. The inference of this study is a strong linkage between homozygous FH and premature aortic calcification. Bazan et al2 have recently described th...

We derive age-metallicity relations (AMRs) and orbital parameters for the 1658 solar neighbourhood stars to which accurate distances are measured by the HIPPARCOS satellite. The sample stars comprise 1382 thin disc stars, 229 thick disc stars, and 47 halo stars according to their orbital parameters. We find a considerable scatter for thin disc AMR along the one-zone Galactic chemical evolution ...

ALBERT, ~VILLIAM C., AND JOSEPH S. HANDLER. EJect of PGEl, indomethacin, and fo&hloretin phosphate on toad bladder response to ADH Am. J. Physiol, 226(6) : 1382-l 386. 1974.-Exogenous PGEr inhibits the short-circuit current response, as well as the water permeability response of the toad bladder to vasopressin. Since PGEI does not inhibit either response to cyclic AMP, it is thought to act by i...