Twin and family studies indicate that smoking addiction is highly influenced by genetic factors. Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression. In this study, we tested five single nucleotide polymorphisms (SNPs) in CRHR1 for their association with ND, which was assessed by smoking quantity (SQ), the Heaviness of Smok...

4-Demethoxydaunorubicin (4-DMDR), an anthracycline analogue available in i.v. and p.o. form, has shown significant antitumor activity in murine tumor models while producing less cardiac toxicity than doxorubicin at equimyelotoxic doses. Phase I and clinical pharmacology studies of the i.v. and p.o. preparation were performed. With i.v. 4-DMDR, consistent myelosuppression was observed at a dose ...

References for these notes are Sections 2.7 and 2.8 as well as Appendicies A2.3, A2.4, and A2.5. of Bjorner and Brenti. There are several supplementary sources listed at the end. Section 2.7 explores the combinatorial structure of the interval between two elements of a coxeter group W , or more generally of a quotient W J . First of all, Corollary 2.5.6 assures us that every maximal chain in [w...

BACKGROUND Poor sleep quality (SQ) is common among patients after coronary artery bypass graft surgery (CABG). This study attempted to determine the status of SQ following an intervention based on the PRECEDE-PROCEED model in patients with poor SQ after CABG. METHODS This study was a randomized clinical trial. The study sample, including 100 patients referred to the Cardiac Rehabilitation Cli...

Tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), a new nucleoside antimetabolite, was evaluated in a phase I trial involving children with refractory cancers. The drug was administered i.v. as a 10-min infusion daily for 5 consecutive days repeated at 3-week intervals. The dose ranged from 550 to 3300 mg/sq m/day. Seventeen patients received 23 courses and were evaluable for toxicity....

In experiments with suspensions of cells from colonic carcinomas, we noted that some colonic carcinomas contain large numbers of eosinophils. We therefore carried out a prospective study with 67 almost consecutive colonic carcinomas in our medical center after optimal fixation and staining for the demonstration of eosinophils. Infiltration of the primary tumor by eosinophils was found to have m...

Drug delivery of combined cytotoxic and antivascular chemotherapies in multidrug nanoassemblies may represent an attractive way to improve the treatment of experimental cancers. Here we made the proof of concept of this approach on the experimental LS174-T human colon carcinoma xenograft nude mice model. Briefly, we have nanoprecipitated the anticancer compound gemcitabine conjugated with squal...

entrepreneurial passion has been shown to have important effect on starting and persistence of entrepreneurial behavior, however its causes has not yet been studied. this paper is aimed at investigating the effect of sq on three types of passion including passion for inventing, founding and developing with the mediating role of ideal entrepreneurial identity centrality. this descriptive survey ...

The serum concentrations of squamous cell carcinoma antigen (SCC-Ag) obtained from 124 surgically treated primary non-small cell lung cancer patients, including 75 adenocarcinomas (AD) and 49 squamous cell carcinomas (SQ), were studied. The changes in the SCC-Ag concentration, which were obtained before and one month after surgery, were analyzed. The 5-year survival rate of the patients with AD...

Light transport in cold atoms: the fate of coherent backscattering in the weak localization regime Y. BIDEL, G. LABEYRIE, T. CHANELIERE, D. WILKOWSKI¶, R. KAISER C. MÜLLER, and C. MINIATURA Christian Miniatura Laboratoire Ondes et Désordre INLN, 1361, route des Lucioles Sophia-Antipolis, 06560 Valbonne France