We report on an XMM-Newton observation of RX J1347.5−1145 (z=0.451), the most luminous X-ray cluster of galaxies currently known, with a luminosity LX = 6.0 ± 0.1 × 10 erg/s in the [2-10] keV energy band. We present the first temperature map of this cluster, which shows a complex structure. It identifies the cool core and a hot region at radii 50-200 kpc to south-east of the main X-ray peak, at...

After the establishment of the first quarantine station in the Republic of Ragusa (modern-day Dubrovnik) in 1377, the states and principalities of Italy developed a sophisticated system of defensive quarantine in an attempt to protect themselves from the ravages of plague. Using largely unknown and unseen historical maps, this paper reconstructs the extent and operation of the system used. It i...

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of skin biology, but its utility is restricted by the requirement fresh samples, inadequate dissociation-induced cell loss or death, and activation during tissue digestion. Here, we profiled cells using single-nucleus (snRNA-seq) in parallel with scRNA-seq. We found that snRNA-seq identified more spatially functionally releva...

Abstract This study seeks to draw connections between the grant proposal peer-review and gender representation in research consortia. We examined implementation of a multi-disciplinary, pan-European funding scheme—EUROpean COllaborative RESearch Scheme (2003–2015)—and reviewers’ materials that this generated. EUROCORES promoted investigator-driven, multinational collaborative multiple scientifi...

Aims, Objectives and Background Advocacy interventions for survivors of domestic violence is well established supported by evidence in some community healthcare settings. Survivors identified emergency departments have important differences it not clear whether can be applied to this population. Therefore, we conducted an inclusive systematic review controlled studies evaluating the effectivene...