In IL-1β (interleukin 1β)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt –1327 to –1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. The corresponding transcription factor was identified to be HNF4α (hepatocyte...

journal.publications.chestnet.org Financial/nonfi nancial disclosures: The author has reported to CHEST the following confl icts of interest: Dr White has research funding from the National Institutes of Health unrelated to the content of this article. He is the president of the American Society of Hypertension, Inc for 2012 to 2014. Dr White is a consultant regarding the cardiovascular safety ...

0360-1315/$ see front matter 2009 Elsevier Ltd. A doi:10.1016/j.compedu.2009.07.005 * Tel.: +34 954556133; fax: +34 954556989. E-mail address: [email protected] Perceived affective quality is an attractive area of research in Information System. Specifically, understanding the intrinsic and extrinsic individual factors and interaction effects that influence Information and Communications Technology...

INTRODUCTION Despite the growing number of oral agents available for cancer treatment, their efficacy may be reduced due to the lack of adherence, inappropriate adverse event self-management and arbitrary dose adjustment. The management of anticancer therapies could exponentially benefit from the introduction of mobile health technologies in a highly integrated electronic oncology system. MET...

BACKGROUND AND OBJECTIVES Academic nephrology faces increasing challenges in faculty hiring and development. However, it is unknown how these pressures have affected the number and demographics of academic nephrologists. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Using the Association of American Medical Colleges Faculty Roster database, changes were analyzed in MD nephrology, as well as o...

Observations of NO, NO2, total peroxy nitrates (6PNs), total alkyl nitrates (6ANs), HNO3, CO, O3, and meteorological parameters were obtained from October 2000 through February 2002 at 1315 m a.s.l., 38.9 N, 120.6 W on Sierra Pacific Industries land, adjacent to the University of California Blodgett Forest Research Station (UC-BFRS). We describe the data set with emphasis on the diurnal cycles ...

Avocado plant (Persea americana), a plant belonging to the family of Lauraceae and genus, persea bears fruit known as avocado pear or alligator pear that contains the avocado pear seed. Reported uses of avocado pear seed include use in the management of hypertension, diabetes, cancer and inflammation [7-9]. The fruit is known as ube oyibo (loosely translated to ‘foreign pear’) in Ojoto and neig...

The activity of the TGF-like ligand Spitz in Drosophila depends on Rhomboid, a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz, thereby releasing the soluble ligand. Several rhomboids in Drosophila have been implicated in the processing of TGF-like ligands, and consequent EGF receptor activation. The larger number of TGF-like ligands ...

lationship), superfamilies (probable common evolutionary origin) and folds (Murzin et al., 1995). Proteins are defined to have a common fold if they have the same major secondary structures in the same spatial arrangement and the same topological connections. SCOP currently distinguishes between several hundred different folds. The (βα)8(or TIM-)barrel is a frequently encountered fold, which co...

Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ/i chain is positively correlated to IDDM. However, Asp57-negative haplotypes do not always confer susceptibility and conversely, some Asp57-positive haplotypes seem to be disease a...