Electroconvulsive shock (ECS) is a highly effective therapy for the treatment of major depression, but its mechanisms of action are not known. We report that repeated ECS in rats produces enduring changes in two clinically relevant stress-responsive brain systems: (a) the hypothalamic-pituitary-adrenal axis regulated by corticotropin-releasing hormone (CRH) in the paraventricular nucleus; and (...

BACKGROUND The World Health Organization has described health systems responsiveness (HSR) as a multi-domain concept encompassing eight non-medical expectations of health-care service seekers. HSR is a valuable measure of health systems performance, providing policy-makers and service providers much information to improve services. This paper presents findings of a cross-sectional survey conduc...

OBJECTIVE To evaluate causes and impact of delay in the door-to-balloon (D2B) time for patients undergoing primary percutaneous coronary intervention (PPCI). SUBJECTS AND METHODS From January 2009 to December 2012, 1268 patients (86% male, mean age of 58 ± 12 years) presented to our hospital for ST-elevation myocardial infarction (STEMI) and underwent PPCI. They were divided into two groups: ...

BACKGROUND The burden of heat illness on health systems is not well described in the UK. Although the UK generally experiences mild summers, the frequency and intensity of hot weather is likely to increase due to climate change, particularly in Southern England. We investigated the impact of the moderate heatwave in 2013 on primary care and emergency department (ED) visits using syndromic surve...

4. Ellison D, Sharppe R, Robbins B, et al. Immunomorphologic analysis of bone marrow biopsies after treatment with 2-chlorodeoxyadenosine for hairy cell leukemia. Blood 1994; 84:4310-5. 5. Konwalinka G, Schirmer M, Hilbe W, et al. Minimal residual disease in hairy-cell leukemia after treatment with 2-chlorodeoxyadenosine. Blood Cells Mol Dis 1995; 21: 142-51. 6. Sarmiento M, Scolnik M, Narbaitz...

This comprehensive cross-sectional study aimed to identify factors contributing to familial aggregation of gastric cancer (GC). A total of 1058 GC patients and 1268 controls were analyzed separately according to the presence or absence of a first-degree relative of GC (GC-relative). Logistic regression analysis adjusted for age, gender, residence during childhood, smoking, alcohol intake, month...

Let w 1 = d, w 2 , ... , w s be the weights of the nonzero codewords in a binary linear [n , k, d] code C, and let w1′ , w2′ , ... , ws ′ ′ be the nonzero weights in the dual code C ⊥ . Let t be an integer in the range 0 < t < d such that there are at most d − t weights wi′ with 0 < wi′ ≤ n − t. Assmus and Mattson proved that the words of any weight w i in C form a t-design. We show that if w 2...

BACKGROUND Organic foreign bodies swell when irrigated with water, potentially making extraction more difficult. As the degree and rate of swelling of different types of organic foreign bodies has not been established, we aimed to analyze the hydroscopic properties of different organic foreign bodies in body temperature water. METHODS Dry kidney beans, brown beans, peas, popcorn kernels, and ...

Proton MR spectroscopic imaging (H-MRSI) of the human prostate, which has an interesting clinical potential, may be improved by increasing the magnetic field strength from 1.5T to 3T. Both theoretical and practical considerations are necessary to optimize the pulse timing for spectroscopic imaging of the human prostate at 3T. For in vivo detection of the strongly coupled spin system of citrate,...