Dependence on Bcl-2 proteins is a common feature of cancer cells and provides a therapeutic opportunity. ABT-737 is an antagonist of antiapoptotic Bcl-2 proteins and therefore is a good predictor of Bcl-xL/ Bcl-2 dependence. Surprisingly, analysis of Mcl-1–dependent multiple myeloma cell lines revealed codependence on Bcl-2/ Bcl-xL in half the cells tested. Codependence is not predicted by the ...

The novel titanium(IV) complexes of composition [TiCl2(SB)2] have been synthesized by reacting TiCl4 and Schiff bases (SBs) where (SBs = A1( tetracycline hydrochloride schiffs base) ;B1(Streptomycin schiffs base ) ;C1( Ceffixime schiffs base) ;D1( ampicillin schiffs base) in fixed molar ratio 1:2. Titanium and chlorine estimation were estimated by gravimetrical and Volhard method respectively. ...

The complex interplay between the abiotic and biotic components of plant communities is precisely whatmakes them so fascinating to study. This complexity, however, is also what makes building predictive models of plant responses to climate change particularly difficult. Prediction into the novel environmental conditions that climate change brings requires mechanistic understanding of the scalin...

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1253 R I. EXPANSION OF THE CONCEPTIONS . . . . . . . . . . . . . . . . . . . . . . . . 1256 R A. The Medical Conception . . . . . . . . . . . . . . . . . . . . . . . . . . . 1256 R B. The Educational Conception . . . . . . . . . . . . . . . . . . . . . . . 1259 R C. The Neurodiversity ...

N Engl J Med 2006;355:1253-61. Copyright © 2006 Massachusetts Medical Society. The deepening of our understanding of normal biology has made it clear that stem cells have a critical role not only in the generation of complex multicellular organisms, but also in the development of tumors. Recent findings support the concept that cells with the properties of stem cells are integral to the develop...

1. Miraglia S, Godfrey W, Yin AH, Atkins K, Warnke R, Holden JT, Bray RA, Waller EK, Buck DW: A novel five-transmembrane hematopoietic stem cell antigen: Isolation, characterization, and molecular cloning. Blood 90:5013, 1997 2. Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW: AC133, a novel marker for human hematopoietic stem and progenitor cel...

Masotti, Keith W. Muir, Anna Paciucci, Francesca Papa, Sabina Roncacci, Dirk Sander, Kerstin Gianfilippo, Cristina Donati, Hedley C.A. Emsley, Sandro Forconi, Stephen J. Hopkins, Luca Mario Di Napoli, Markus Schwaninger, Roberto Cappelli, Elena Ceccarelli, Giacinto Di Project Members Ischemic Stroke : A Statement for Health Care Professionals From the CRP Pooling Evaluation of C-Reactive Protei...

BACKGROUND AND PURPOSE Childhood arterial ischemic stroke treatment guidelines recommend extended anticoagulation in cardioembolism and dissection. We sought to investigate the safety of extended anticoagulation in childhood arterial ischemic stroke with nonmoyamoya arteriopathy, for which the risk of recurrent stroke is high. METHODS Thirty-seven patients with childhood-onset arterial ischem...

1. Miraglia S, Godfrey W, Yin AH, Atkins K, Warnke R, Holden JT, Bray RA, Waller EK, Buck DW: A novel five-transmembrane hematopoietic stem cell antigen: Isolation, characterization, and molecular cloning. Blood 90:5013, 1997 2. Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW: AC133, a novel marker for human hematopoietic stem and progenitor cel...