Cl(-) currents induced by cell swelling were characterized in an immortalized cell line (DC1) derived from rabbit distal bright convoluted tubule by the whole cell patch-clamp techniques and by (125)I(-) efflux experiments. Exposure of cells to a hypotonic shock induced outwardly rectifying Cl(-) currents that could be blocked by 0.1 mM 5-nitro-2-(3-phenylpropyl-amino)benzoic acid, 1 mM DIDS, a...

We have previously shown that, monoclonal antibodies (mAbs) labeled with the Auger electron emitter I are more in vitro, 125 cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed the biological efficiency in vivo of internalizing and non internalizing I-labeled mAbs for the treatment of small solid tumors. 125

OBJECTIVE The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients. METHOD Cross-sectional study. RESULTS 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 pa...

BACKGROUND Cancer antigen 125 (CA 125), a widely used tumor marker for monitoring epithelial ovarian cancer, is also found to be raised in non-gynecological tumors and non malignant disease involving peritoneum. We report a case of non-Hodgkin's lymphoma who presented with peritoneal and pleural effusions with a very high level of serum CA 125. CASE Fifty four years female presented with gros...

36 Martin, K. I,., Brown, C. K., Lignappa, J. K., Lignappa, V. K. and Welch, W. J. (1993) Mol. Hiol. Cell. 4, (Suppl.) 95a Frydman, J., Nimmesgern, E., Ohtsuka, K. and Hartl, F.-U. ( 1994) Nature (London) 370, 1 1 1 1 17 Lignappa, J. K., Martin, R. L., Wong, M. L., Ganem, D.? Welch, W. J. and Lignappa, V. K. (1994) J. Cell Hiol. 125, 99-1 11 Cheetham, M. E., Brion, J.-1’. and Anderton, H. H. (1...

To date, only a few reports about studies on toxic effects of carbon nanotubes (CNT) are available, and their results are often controversial. Three different cell lines (rainbow trout liver cells (RTL-W1), human adrenocortical carcinoma cells (T47Dluc), and human adrenocarcinoma cells (H295R)) were exposed to multiwalled carbon nanotubes, the antimicrobial agent triclocarban (TCC) as well as t...