•Expedient assembly of the conidiogenone core via nitrile-assisted TMM diyl cycloaddition•Regio- and diastereoselective decorations D-ring scaffold•Divergent synthesis six (?)-conidiogenones•First total (?)-conidiogenones E, F, 12?-hydroxyconidiogenone C Herein, we constructed fused tetracyclic natural products by single-step tandem cyclizations diazo, allene, olefin moieties in linear precurso...

The effect of GH substitution on serum lipids and lipoproteins, and in particular lipoprotein(a) (Lp(a)), was investigated in 32 adults with postoperative (acquired) GH deficiency as part of a double-blind, placebo-controlled trial. Seventeen men and fifteen women, aged 18-59 years (mean 42 years) from two centres (Hannover and Göttingen) were randomly assigned to two groups. Group P (placebo) ...

Cobalt not only is an essential micronutrient for mammals but also marks itself as important in organic synthesis, especially the field of catalysis. Various useful reactions, such alkene hydroformylation, hydrogenation, heterofunctionalizations carbon–carbon double bonds, C–H activation, and cross-coupling have been realized with aid this metal. At same time, cobalt deserves special attention ...