We investigated an imaging strategy that provides simultaneous measurements of radiotracer binding and behavior in awake, freely moving animals. In this strategy, animals are injected intravenously (i.v.) through a catheterized line and permitted to move freely for 30 min during uptake of the imaging agent, in this case 11C-raclopride. After this Awake Uptake period, animals are anesthetized an...

Original Article Context: Cilnidipine, an N-type and L-type calcium channel blocker has been reported to have antihypertensive, renoprotective and neuroprotective effect. In this present study we evaluated anti-epileptic effect of cilnidipine in experimentally induced convulsions in Mice. Aims: To evaluate the anti epileptic effect of cilnidipine. Materials and Methods: Cilnidipine, phenytoin s...

This calculator uses the revised versions of the Winter-Tozer correction this method has now been shown to poorly correlated with free phenytoin levels., . Phenytoin. μg/mL. Albumin. g/dL. Creatinine clearance < 20 ml/min. No. Yes. About the Creator. Dr. Thomas N. Tozer. Related Calcs. Ca Correction for Albumin . Jul 25, 2017. The program accomplishes this by utilizing the Sheiner-Tozer equatio...

OBJECTIVE This study was undertaken to measure serotonergic modulation of dopamine in vivo by using positron emission tomography (PET), a radiotracer for the striatal dopamine D2 receptor ([11C]raclopride), and a pharmacologic challenge of the serotonin system (d,l-fenfluramine). METHOD Two PET studies using [11C]raclopride were performed in 11 normal male subjects before administration of th...

The present study was conducted to investigate the 11C‑Choline metabolic mechanism and examine the association between 11C‑Choline metabolism and uptake in different pathological types of lung cancer. A total of 18 tumor specimens and corresponding normal lung tissues were collected from patients who were diagnosed with lung cancer using 11C‑Choline positron emission tomography (PET)/computed t...

In quantitative PET measurements, the analysis of radiometabolites in plasma is essential for determining the exact arterial input function. Diphenyl sulfide compounds are promising PET and SPECT radioligands for in vivo quantification of the serotonin transporter (SERT) and it is therefore important to investigate their radiometabolism. We have chosen to explore the radiometabolic profile of [...

STUDY OBJECTIVE To determine the value of fosphenytoin compared with phenytoin for treating patients admitted to an emergency department following a seizure. DESIGN Cost-minimization analysis performed from a hospital perspective. SETTING Hospital emergency department. PATIENTS Two hundred fifty-six patients participating in a comparative clinical trial. INTERVENTION Estimation of adver...

The major phenytoin metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin glucuronide (HPPG), was primarily responsible for the positive bias noted when uremic specimens were assayed with the Abbott TDx Free Phenytoin fluorescence polarization immunoassay. The amount of bias depended on both HPPG and phenytoin concentration, increasing with increases in either concentration. The new Abbott TDx II a...

Hallucinogens are a loosely defined group of compounds including LSD, N,N-dimethyltryptamines, mescaline, psilocybin/psilocin, and 2,5-dimethoxy-4-methamphetamine (DOM), which can evoke intense visual emotional experiences. We witnessing renaissance research interest in hallucinogens, driven by increasing awareness their psychotherapeutic potential. As such, we now present narrative review the ...

PURPOSE To evaluate the reproducibility of 2-[11C]thymidine positron emission tomography (PET) scanning in patients with advanced intra-abdominal malignancies. PATIENTS AND METHODS The reproducibility of 2-[11C]thymidine PET was studied by comparing interpatient and intrapatient variability (coefficient of variability, COV) of both blood and tissue data. Arterial plasma metabolite levels were...