The presence of paranoid thoughts is not exclusive to clinical disorder; recent data suggest that their prevalence follows an exponential-shaped curve, with many people experiencing a few such thoughts, while a few people experience many such thoughts. Wong et al (pp. 221–229) found that this exponential curve was also evident in their assessment of paranoid thoughts in children, but the freque...

BACKGROUND/AIMS The purpose of this study was to investigate the malignant potential of aberrant crypt foci (ACF) by measuring the multiplicity of crypts and lectin expression in the early and late stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis. METHODS Six-week-old Wistar rats were injected subcutaneously with DMH for 27 weeks. We classified ACF according to the number of...

The effects of the carcinogen, 1,2-dimethylhydrazine (DMH), on the proliferative characteristics of the crypt cell population of mouse colon were studied. DMH (20 mg/kg body weight) was injected s.c., weekly, for 2, 8, 16, 20, or 26 weeks. At the end of each treatment period, a group of animals was injected with [3H]thymidine and killed. After 2 weeks of DMH treatment, the crypts appeared norma...

Previous self-harm is a major predictor of non-fatal repetition and subsequent suicide. Owens et al (pp. 193–199), in a systematic review, estimate the rates of these outcomes following self-harm and find the link between self-harm and suicide to be a strong one. Non-fatal repetition occurred in around 15% of people in the year after an attempt, with up to 2% committing suicide over this time. ...

A stroma-dependent cell line (HB-1) was established from myelogenous leukemic cells of CBA/N mouse. Characterization of the cells showed that HB-1 proliferated on hematopoietic supportive stromal cells (MS-10), but did not survive or proliferate on hematopoietic nonsupportive cells (MS-K). Direct contact between HB-1 and MS-10 appears to be necessary for HB-1 to proliferate on MS-10. We found t...