Endophilin and Sorting Nexin 9 (Snx9) play key roles in endocytosis by membrane curvature sensing and remodeling via their Bin/Amphiphysin/Rvs (BAR) domains. BAR and the related F-BAR domains form dimeric, crescent-shaped units that occur N- or C-terminally to other lipid-binding, adaptor, or catalytic modules. In crystal structures, the PX-BAR unit of Snx9 (Snx9(PX-BAR)) adopts an overall comp...

This paper describes a general approach to constructing cooperative services that span multiple administrative domains. In such environments, protocols must tolerate both rational behaviors when nodes arbitrarily deviate from the protocol for their local benefit and Byzantine behaviors when a broken, misconfigured, or malicious node arbitrarily deviates from the protocol for any other reason. T...

Abstract Inspired by the fully heavy tetraquark states reported LHCb, ATLAS and CMS Collaborations, we perform a systematical investigation of low-lying pentaquark systems composed charm bottom quarks (anti-quark) in chiral quark model. With help channel-coupling, obtain several candidates, which are $$cccc\bar{b}$$ c<...

The effect of anti-sense RNA on the expression of the bialaphos resistance (bar) gene which encodes phosphinothricin acetyl transferase (PAT), was analysed in tobacco. Transient expression studies revealed that an anti-bar RNA with sequence complementarity to the complete bar coding region, inhibits PAT synthesis. To quantify the phenomenon, SR1 tobacco cells were transformed twice to introduce...

We present a microchip-based, voltage-addressable on/off valve architecture that is fundamentally consistent with the pressures and solvents employed for high-pressure liquid chromatography. Laser photopatterning of polymer monoliths inside glass microchannels is used to fabricate mobile fluid control elements, which are opened and closed by electrokinetic pressures. The glass substrates and cr...

pediatric mandibular fractures have been successfully managed in various ways. the use of a lingual splint is an option. this article presents a 4-year old boy who was treated by an alternative conservative method with a combination of an arch bar plus a lingual splint, circum-mandibular wiring and imf for the reduction, stabilization and fixation of a severely displaced bilateral man dibular b...

We study the characteristics of molecular gas in the central regions of spiral galaxies on the basis of our CO(J=1–0) imaging survey of 20 nearby spiral galaxies using the NRO and OVRO millimeter arrays. Condensations of molecular gas at galactic centers with sizescales ∼< 1 kpc and CO-derived masses Mgas(R < 500pc) ∼ 10 8 – 10 M⊙ are found to be prevalent in the gas-rich ∼ L ∗ galaxies. Moreov...