water and temperature are determinant factors for seed germination. both factors can, separately or jointly, affect the germination percentage and germination rate. the effect of temperature on germination and water potential on germination can often be described by the thermal time and hydrotime models, respectively. additionally, the thermal time model and the hydrotime model have been combin...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

objectives : this finite element method study aimed to compare the amount of stress on an isolated mandibular second premolar in two conventional reciprocal parallel interface designs of removable partial dentures (rpds) and the same rpd abutment tooth (not isolated). materials and methods: a kennedy class 1, modification 1 rpd framework was simulated on a 3d model of mandible with three differ...

It is currently being debated whether pharmacokinetic monitoring of mycophenolic acid (MPA), the active constituent of mycophenolate mofetil (MMF), can optimize MMF therapy after organ transplantation. This open-label longitudinal study in pediatric renal transplant recipients was designed to investigate the pharmacokinetic (PK)/pharmacodynamic relationship of total and free MPA and to establis...

in this study the feasibility of using salep as a new film-forming material was studied. the mechanical properties, water vapor permeability and thickness of salep films incorporated with glycerol were determined. increasing the content of dry material of salep from 1% to 3%(w/v) increased values for tensile strength and elongation at break from 16.16% and 18.85 mpa to 70.15% and 24.50 mpa resp...

BACKGROUND Some studies of nosocomial bloodstream infection (nBSI) have demonstrated a higher mortality for polymicrobial bacteremia when compared to monomicrobial nBSI. The purpose of this study was to compare differences in systemic inflammatory response and mortality between monomicrobial and polymicrobial nBSI with Pseudomonas aeruginosa. METHODS We performed a historical cohort study on ...

Natural progesterone, a potent respiratory stimulant, stimulates leptin production in premenopausal females. Leptin and its counterpart neuropeptide Y (NPY) have recently been linked with respiration. The effect of medroxyprogesterone acetate (MPA) on arterial blood gases, serum leptin and NPY was evaluated in this study. Fourteen postmenopausal females with respiratory impairment, due mostly t...

A new mycophenolate (MPA) assay based on the enzymatic activity of recombinant type II inosine monophosphate dehydrogenase (the pharmacological target of MPA) with excellent correlation with high-performance liquid chromatography has recently been released for the measurement of MPA plasma levels. This study aimed to (1) compare this new assay with liquid chromatography tandem mass spectrometry...

This study aimed to evaluate the trypanocidal activity of mycophenolic acid (MPA) and its derivatives for Trypanosoma congolense The proliferation of T. congolense was completely inhibited by adding <1 μM MPA and its derivatives. In addition, the IMP dehydrogenase in T. congolense was molecularly characterized as the target of these compounds. The results suggest that MPA and its derivatives ha...