نتایج جستجو برای: 1 dna vaccine

تعداد نتایج: 3216706  

2009
George Jiang Meng Shi Solomon Conteh Nancy Richie Glenna Banania Harini Geneshan Anais Valencia Priti Singh Joao Aguiar Keith Limbach Kurt I. Kamrud Jonathan Rayner Jonathan Smith Joseph T. Bruder C. Richter King Takafumi Tsuboi Satoru Takeo Yaeta Endo Denise L. Doolan Thomas L. Richie Walter R. Weiss

Using newer vaccine platforms which have been effective against malaria in rodent models, we tested five immunization regimens against Plasmodium knowlesi in rhesus monkeys. All vaccines included the same four P. knowlesi antigens: the pre-erythrocytic antigens CSP, SSP2, and erythrocytic antigens AMA1, MSP1. We used four vaccine platforms for prime or boost vaccinations: plasmids (DNA), alphav...

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Journal: :Iranian journal of immunology : IJI 2012
Rohollah Dorostkar Taravat Bamdad Masoud Parsania Hassan Pouriayevali

BACKGROUND Improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. Necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen synthesis as well as its ability to stimulate the maturation of dendritic cells. OBJECTIVE T...

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Journal: :Journal of immunology 1999
G J Fennelly S A Khan M A Abadi T F Wild B R Bloom

An intranasal vaccine vector would elicit protective immunity at the respiratory mucosa, the portal of entry and the primary site for replication for measles virus (MV) and other respiratory viruses. In a murine model of pulmonary Shigella, we demonstrate here that a candidate-attenuated Shigella vaccine vector is safely tolerated in IFN-gamma deficient mice at an inoculum that is 1 million-fol...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
R Xiang H N Lode T H Chao J M Ruehlmann C S Dolman F Rodriguez J L Whitton W W Overwijk N P Restifo R A Reisfeld

We demonstrated that peripheral T cell tolerance toward murine melanoma self-antigens gp100 and TRP-2 can be broken by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to minigenes encoding peptide epitopes gp100(25-33) and TRP-2(181-188). These epitopes contain dominant anchor residues for MHC class I antigen alleles H-2D(b) and H-2K(b), respectively. The DNA vaccine w...

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Journal: :Journal of acquired immune deficiency syndromes 2012
Jessica A Kahn Robert D Burk Kathleen E Squires Bill G Kapogiannis Bret Rudy Jiahong Xu René Gonin Nancy Liu Carol Worrell Craig M Wilson

BACKGROUND The objectives of this study were to describe the prevalence and risk factors for HPV infection among HIV-infected young women receiving their first quadrivalent HPV (HPV-6, -11, -16, and -18) vaccine dose. METHODS We recruited 16- to 23-year-old women from 14 sites for an HPV vaccine trial. At the first visit, they completed a questionnaire and were tested for cervicovaginal HPV D...

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2014
Yingying Xu Pak-Wai Yuen Jenny Ka-Wing Lam

Intranasal delivery of DNA vaccines has become a popular research area recently. It offers some distinguished advantages over parenteral and other routes of vaccine administration. Nasal mucosa as site of vaccine administration can stimulate respiratory mucosal immunity by interacting with the nasopharyngeal-associated lymphoid tissues (NALT). Different kinds of DNA vaccines are investigated to...

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2014
Devon J. Shedlock Colleen Tingey Lavanya Mahadevan Natalie Hutnick Emma L. Reuschel Sagar Kudchodkar Seleeke Flingai Jenny Yan Joseph J. Kim Kenneth E. Ugen David B. Weiner Kar Muthumani

DNA vaccine-induced immunity can be enhanced by the co-delivery of synthetic gene-encoding molecular adjuvants. Many of these adjuvants have included cytokines, chemokines or co-stimulatory molecules that have been demonstrated to enhance vaccine-induced immunity by increasing the magnitude or type of immune responses and/or protective efficacy. In this way, through the use of adjuvants, immune...

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Journal: :The Journal of clinical investigation 2004
Shawn M Sumida Paul F McKay Diana M Truitt Michael G Kishko Janelle C Arthur Michael S Seaman Shawn S Jackson Darci A Gorgone Michelle A Lifton Norman L Letvin Dan H Barouch

DCs are critical for priming adaptive immune responses to foreign antigens. However, the utility of harnessing these cells in vivo to optimize the immunogenicity of vaccines has not been fully explored. Here we investigate a novel vaccine approach that involves delivering synergistic signals that both recruit and expand DC populations at the site of antigen production. Intramuscular injection o...

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2015
Karine M Forster Daiane D Hartwig Thaís L Oliveira Kátia L Bacelo Rodrigo Schuch Marta G Amaral Odir A Dellagostin

Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of the Leptospira genus. Vaccination with bacterins has severe limitations. Here, we evaluated the N-terminal region of the leptospiral immunoglobulin-like B protein (LigBrep) as a vaccine candidate against leptospirosis using immunisation strategies based on DNA prime-protein boost, DNA vaccine, and subunit vaccine. Upon chal...

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Journal: :Journal of immunology 2008
Daejin Kim Talia Hoory Archana Monie Jenny Pan-Yun Ting Chien-Fu Hung T-C Wu

Administration of DNA vaccines via gene gun has emerged as an important form of Ag-specific immunotherapy. The MHC CIITA is a master regulator of MHC class II expression and also induces expression of class I molecules. We reasoned that the gene gun administration of CIITA DNA with DNA vaccines employing different strategies to improve MHC I and II processing could enhance DNA vaccine potency. ...

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