OBJECTIVE Interleukin-1β (IL-1β) is a major cytokine linking inflammation and angiogenesis in pathological vascular processes, such as atherosclerosis and tumor neoangiogenesis. However, signaling pathways mediating IL-1β-induced proangiogenic processes in endothelial cells (ECs) have barely been elucidated yet. Therefore, the present study investigated IL-1β-induced proangiogenic signaling in ...

AIM BACKGROUND AND OBJECTIVES IL-1β is a potent stimulator of bone resorption and has been implicated in the pathogenesis of periodontal destruction. Therefore, this study was designed to compare the levels of IL-1β of chronic periodontitis patients with the healthy subjects. Another objective of this study was to correlate IL-1β levels with the clinical parameters of the periodontal disease...

Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which a canonical mechanism of secretion remains to be established. Neutrophils are essential players against bacterial and fungi infections. These cells are rapidly and massively recruited from the circulation...

In the aged brain, synaptic plasticity and memory show increased vulnerability to impairment by the inflammatory cytokine interleukin 1β (IL-1β). In this study, we evaluated the possibility that synapses may directly undergo maladaptive changes with age that augment sensitivity to IL-1β impairment. In hippocampal neuronal cultures, IL-1β increased the expression of the IL-1 receptor type 1 and ...

introduction: helicobacter pylori (h. pylori), is a bacterium responsible for upper gastrointestinal tract diseases. the 16s rrna is a common h. pylori gene which are usually preferred for diagnosis purpose. the aim of this study was to determine the prevalence and abundance of 16s rrna in fecal samples and also evaluate correlation between the level of 16s rrna and activities of the cytokines,...

we and other studies have elucidated single molecules that can attenuate aging and extend longevity. indeed, these molecules could prevent age-associated diseases simultaneously and probably extending healthy-life spans. in this review, we discuss recent advances, controversies, opportunities and challenges surrounding ursolic acid (ua) in relationship with aging. in this regard, ua also known ...

Objective : to evaluate the significance of clinical indicators, expression pain syndrome genes cathepsin S and pro-inflammatory cytokines in peripheral blood for predicting development postoperative (POP) patients with hip osteoarthritis (HOA) before total arthroplasty (TA). Material methods. The study included 31 stages III–IV HOA (mean age 61.3±9.8 years) who underwent TA 26 healthy voluntee...

Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) may coexist in elderly patients with a history of smoking. Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in patients primarily diagnosed with COPD, and nonreversible airflow limitation in patients primari...

Telocytes (TCs), a distinct interstitial cell population, have been identified in the uterus, oviduct and placenta, with multiple proposed potential biological functions. Their unique structure allows them to form intercellular junctions with various immunocytes, both in normal and diseased tissues, suggesting a potential functional relationship with the local immune response. It has been hypot...

We have previously shown that increases in blood-brain barrier permeability represent an important component of ischemia-reperfusion related brain injury in the fetus. Pro-inflammatory cytokines could contribute to these abnormalities in blood-brain barrier function. We have generated pharmacological quantities of mouse anti-ovine interleukin-1β monoclonal antibody and shown that this antibody ...