The topic of the specific surface area (SSA) of powders is not sufficiently described in the literature in spite of its nontrivial contribution to adsorption and dissolution processes. Fractal geometry provides a way to determine this parameter via relation SSA ~ x(D ́ 3)s(2 ́ D), where x (m) is the particle size and s (m) is a scale. Such a relation respects nano-, micro-, or macro-topography on...

The 'new view' of proteins sees protein reactions as parallel processes occurring along funnelled energy landscapes. These landscapes are generally not smooth, but are superimposed by hills and valleys of different heights and widths leading to roughness on the energy surface. In the present paper, we describe the origins of protein energy landscape roughness, measurements of its scale and its ...

Identifying and assessing the relative effects of the numerous determinants of malaria transmission, at different spatial scales and resolutions, is of primary importance in defining control strategies and reaching the goal of the elimination of malaria. In this context, based on a knowledge-based model, a normalized landscape-based hazard index (NLHI) was established at a local scale, using a ...

The majority of tidal channels display marked meandering features. Despite their importance in oil-reservoir formation and tidal landscape morphology, questions remain on whether tidal-meander dynamics could be understood in terms of fluvial processes and theory. Key differences suggest otherwise, like the periodic reversal of landscape-forming tidal flows and the widely accepted empirical noti...

Wetlands have value because their functions have proved to be useful to humans. The unit value for some wetlands also increases with human development (agriculture and urban) because of increased use and/or increased scarcity. Yet, paradoxically, its functions can easily be overwhelmed in areas of heavy human development, thus lessening those values. Thus wetlands appear to work best in the lan...

The interaction between human activity and landscape pattern has been a hot research topic during the last few decades. However, scholars used to measure human activity by social, economic and humanistic indexes. These indexes cannot directly reflect human activity and are not suitable for fine-grained analysis due to the coarse spatial resolution. In view of the above problems, this paper prop...

Understanding the causes of the intra-urban air temperature variability is a first step in improving urban landscape design to ameliorate urban thermal environment. Here we investigated the spatial and temporal variations of air temperature at a local scale in Beijing, and their relationships with three categories of landscape design parameters, including the land cover features, site geometry,...

This SnapShot summarizes current knowledge about the key features in mutational landscape, major pathways, and tumor evolution and heterogeneity in renal cell carcinoma, as well as the most recent advances in therapeutic development. To view this SnapShot, open or download the PDF.

Abstract This article argues that an expanded view of linguistic landscapes provides a useful metaphor for exploring language policies. Following this view, “language policy” is defined as “linguistic landscaping” (i.e., placing policy mechanisms which, together with already placed mechanisms, construct metaphorical landscape). The application landscaping has several advantages, it way to imagi...

MOTIVATION Transcriptional regulation is directly enacted by the interactions between DNA and many proteins, including transcription factors (TFs), nucleosomes and polymerases. A critical step in deciphering transcriptional regulation is to infer, and eventually predict, the precise locations of these interactions, along with their strength and frequency. While recent datasets yield great insig...