Phytochemical screening and antimicrobial activity of chloroform, acetone and methanolic extracts of Calotropis procera (Ait.) R. Br. (Asclepiadaceae) flowers were tested against various pathogens such as Salmonella paratyphi, S. paratyphi A, Bacillus subtilis, Bacillus thuringiensis, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. Phytoc...

BackgroundMultiple early reports of patients admitted to hospital with COVID-19 showed that chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised the widespread use inhaled glucocorticoids among was responsible for this finding, and tested if would be an effective treatment COVID-19.MethodsWe performed open-label, parallel-group, phase 2, randomised ...

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility...

Department of Chemistry, Avinashilingam Deemed University for Women, Coimbatore641 043 ABSTRACT Lipophilicity which plays an important role in research into the structure-activity relationship of drug action has been theoretically predicted for few chromen-2-ones and chromen-2-thiones using commercial software HyperChem 7.0 and an internet computational software ALOGPS 2.1. In the compounds ana...