BACKGROUND AND OBJECTIVE Multidrug therapy in leprosy has failed to eliminate the problem of persister bacilli. Clearance of bacterial antigens is extremely slow which could predispose to continued nerve damage even after release from treatment. In the present study the immunomodulatory efficacy of BCG vaccine administered post-MDT in BL-LL leprosy patients was investigated in depth with a view...

Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications. However, a wide variety of safety concerns, especially those related to oral exposure, still need to be addressed for iron oxide nanoparticles in order to reach clinical practice. Here, we report on the effects of chronic oral exposure to low doses of ...

Graphene (GR) has huge industrial and biomedical potential, its adverse effect on soil microorganisms been evaluated in ecotoxicological studies. These studies focused single exposure to GR, but repeated exposures with low concentration are more likely occur under actual scenario. In this study, we compared the impact of GR structure, abundance function bacterial community based enzyme activity...

Magnetite Fe3O4 nanoparticles (NPs) were prepared by chemical coprecipitation method. Silica-coated magnetite NPs were prepared by sol-gel reaction, subsequently coated with 3-aminopropyltriethoxysilane (APTES) via silanization reaction, and then were activated with 2,4,6-trichloro-1,3,5-triazine (TCT) and covalently immobilized with bovine serum albumin (BSA). The size and structure of the par...

High specific strength and superior corrosion resistance are two key characteristics of the aerospace grade AA7075-T6 alloy. However, surface behavior is found to be deprived, because its being prone fretting fatigue adhesive wear under dry sliding conditions. Thus, improvement with retention microhardness alloy required for increasing wider application. For this, isomorphous precipitates soft ...

Intravenous injection of substance P (SP) increases renal nerve firing and heart rate in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) by stimulating sympathetic ganglia. Blood pressure is increased in SHRs but lowered in WKYs. This study assesses the role of neurokinin-1 (NK(1)) receptors in mediating the ganglion actions of SP. Rats for functional studies were anesthetiz...