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1 cancer 2 3 Authors and Affiliations: Stefan E. Pool, S. Bison, Stuart J. Koelewijn, Linda M. van der Graaf, 4 Marleen Melis, Eric P. Krenning, Marion de Jong 5 6 Department of Nuclear Medicine and Radiology, Erasmus MC, Rotterdam, the Netherlands 7 8 None of the authors has a conflict of interest to declare. 9 10 Running title: Augmentation of metastatic tumor behavior by mTOR inhibition. 11 12
Isolated activation of metabolically sensitive skeletal muscle afferents (muscle metaboreflex) using post-exercise ischaemia (PEI) following handgrip partially maintains exercise-induced increases in arterial blood pressure (BP) and muscle sympathetic nerve activity (SNA), while heart rate (HR) declines towards resting values. Although masking of metaboreflex-mediated increases in cardiac SNA b...
Portal blood flow (litres/min)† 2·77 2·15 2·87 0·29 NS‡ ,0·001 NS Net portal flux (mmol/h) Glucose 258 203 242 21 0·20 ,0·001 ,0·001 Insulin flux (nmol/h)§ 9·0 3·6, 15·7 10·5 4·8, 17·5 4·6 0·01,10·2 – 0·09 0·04 NS C-peptide (nmol/h)§ 7·9 4·6, 11·4 6·6 3·4, 10·0 5·5 2·4, 8·8 – NS ,0·001 NS GLP-1 (nmol/h)§ 1·6 1·2, 2·0 1·8 1·4, 2·2 1·9 1·4, 2·3 – NS ,0·001 NS GIP (nmol/h)§ 4·4 2·1, 6·9 2·8 0·5, 5...
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